Spink5 serine peptidase inhibitor, Kazal type 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Spink5provided by RGD
Full Name: serine peptidase inhibitor, Kazal type 5provided by RGD
Primary source: RGD:1306540
See related: EnsemblRapid:ENSRNOG00000013116 AllianceGenome:RGD:1306540
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in epidermal cell differentiation; negative regulation of antibacterial peptide production; and negative regulation of serine-type endopeptidase activity. Predicted to act upstream of or within negative regulation of serine-type peptidase activity and regulation of cell adhesion. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; epidermal lamellar body; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Netherton syndrome. Orthologous to human SPINK5 (serine peptidase inhibitor Kazal type 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 31.5), Thymus (RPKM 2.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 18q11

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (36515347..36584038)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (36264452..36333143)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (35118300..35190458)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Spink5 (e-PCR), detects polymorphism
- UniSTS:502673

RH133717 (e-PCR)
- UniSTS:217000

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of serine-type peptidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in epidermal lamellar body	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine protease inhibitor Kazal-type 5

Names: serine protease inhibitor Kazal-type 5-like; serine protease inhibitor, Kazal type 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170606.1 → NP_001164077.1 serine protease inhibitor Kazal-type 5 precursor

See identical proteins and their annotated locations for NP_001164077.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A6KUC9, D3ZET2

Related

ENSRNOP00000017522.6, ENSRNOT00000017522.10

Conserved Domains (4) summary

smart00280
Location:576 → 616

KAZAL; Kazal type serine protease inhibitors

cd01327
Location:954 → 998

KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...

pfam07648
Location:442 → 476

Kazal_2; Kazal-type serine protease inhibitor domain

cl00097
Location:651 → 675

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...