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    Klhl42 kelch-like family, member 42 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500367, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Klhl42provided by RGD
    Official Full Name
    kelch-like family, member 42provided by RGD
    Primary source
    RGD:1560924
    See related
    EnsemblRapid:ENSRNOG00000001844 AllianceGenome:RGD:1560924
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Klhdc5; RGD1560924
    Summary
    Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of microtubule-based process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human KLHL42 (kelch like family member 42). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Adrenal (RPKM 76.3), Spleen (RPKM 72.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl42 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (181730343..181760899)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (179999655..180027283)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (181481147..181502916)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RAB15 effector protein Neighboring gene mitochondrial ribosomal protein S35 Neighboring gene MANSC domain containing 4 Neighboring gene uncharacterized LOC134486873 Neighboring gene transcription elongation factor A1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. Cummings CM, et al. J Biol Chem, 2009 Apr 24. PMID 19261606, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 42
    Names
    kelch domain containing 5
    kelch domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109257.1 → NP_001102727.1  kelch-like protein 42

      Status: PROVISIONAL

      Source sequence(s)
      CH473964
      UniProtKB/TrEMBL
      A6IN41, D4A9Z3
      Related
      ENSRNOP00000002523.5, ENSRNOT00000002523.7
      Conserved Domains (4) summary
      PHA03098
      Location:198 → 485
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:232 → 275
      Kelch; KELCH repeat [structural motif]
      cd18319
      Location:4 → 101
      BTB_POZ_KLHL42; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42)
      cd18478
      Location:113 → 225
      BACK_KLHL42_KLHDC5; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      181730343..181760899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286601.1 → XP_063142671.1  kelch-like protein 42 isoform X2

    2. XM_063286602.1 → XP_063142672.1  kelch-like protein 42 isoform X2

    3. XM_063286600.1 → XP_063142670.1  kelch-like protein 42 isoform X1

    4. XM_063286605.1 → XP_063142675.1  kelch-like protein 42 isoform X4

    5. XM_063286603.1 → XP_063142673.1  kelch-like protein 42 isoform X3

    6. XM_063286604.1 → XP_063142674.1  kelch-like protein 42 isoform X4

    7. XM_063286606.1 → XP_063142676.1  kelch-like protein 42 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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