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    Tnfrsf14 TNF receptor superfamily member 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366518, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Tnfrsf14provided by RGD
    Official Full Name
    TNF receptor superfamily member 14provided by RGD
    Primary source
    RGD:1310115
    See related
    EnsemblRapid:ENSRNOG00000013820 AllianceGenome:RGD:1310115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytokine binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including defense response to bacterium; negative regulation of adaptive immune memory response; and regulation of T cell activation. Predicted to act upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation and positive regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of myocardial infarction. Orthologous to human TNFRSF14 (TNF receptor superfamily member 14). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 200.7), Thymus (RPKM 90.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnfrsf14 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (170768413..170776749, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (165486069..165494421, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172328259..172337221, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene membrane metallo-endopeptidase-like 1 Neighboring gene peroxiredoxin like 2B Neighboring gene hes family bHLH transcription factor 5 Neighboring gene pantothenate kinase 4 Neighboring gene phospholipase C, eta 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure. Dahl CP, et al. Eur J Heart Fail, 2008 Apr. PMID 18353719
    2. Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases. Lee WH, et al. Arterioscler Thromb Vasc Biol, 2001 Dec. PMID 11742877
    3. LIGHT/TNFSF14 enhances adipose tissue inflammatory responses through its interaction with HVEM. Kim HM, et al. FEBS Lett, 2011 Feb 4. PMID 21236258
    4. CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator. Cai G, et al. Nat Immunol, 2008 Feb. PMID 18193050
    5. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. Tamada K, et al. J Immunol, 2000 Apr 15. PMID 10754304

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108903

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of CD4-positive, alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of T cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of adaptive immune memory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of alpha-beta T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 14
    Names
    tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015034.1 → NP_001015034.1  tumor necrosis factor receptor superfamily member 14 precursor

      Status: VALIDATED

      Source sequence(s)
      BC091202
      UniProtKB/TrEMBL
      F7F4X8, Q5BK53
      Related
      ENSRNOP00000018492.7, ENSRNOT00000018494.7
      Conserved Domains (3) summary
      cd00185
      Location:136 → 199
      TNFRSF; CRD2 [structural motif]
      cd10582
      Location:40 → 140
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
      cl22855
      Location:97 → 204
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      170768413..170776749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288145.1 → XP_063144215.1  tumor necrosis factor receptor superfamily member 14 isoform X6

    2. XM_039110510.2 → XP_038966438.1  tumor necrosis factor receptor superfamily member 14 isoform X7

      Conserved Domains (2) summary
      cd00185
      Location:96 → 155
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
      cl22855
      Location:34 → 102
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    3. XM_063288148.1 → XP_063144218.1  tumor necrosis factor receptor superfamily member 14 isoform X10

    4. XM_063288147.1 → XP_063144217.1  tumor necrosis factor receptor superfamily member 14 isoform X9

    5. XM_006239587.5 → XP_006239649.1  tumor necrosis factor receptor superfamily member 14 isoform X5

      UniProtKB/TrEMBL
      F7F4X8
      Conserved Domains (3) summary
      cd00185
      Location:148 → 211
      TNFRSF; CRD2 [structural motif]
      cd10582
      Location:52 → 152
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
      cl22855
      Location:109 → 216
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    6. XM_039110509.2 → XP_038966437.1  tumor necrosis factor receptor superfamily member 14 isoform X2

      UniProtKB/TrEMBL
      F7F4X8
      Conserved Domains (3) summary
      cd00185
      Location:109 → 145
      TNFRSF; CRD1 [structural motif]
      cd10582
      Location:52 → 152
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
      cl22855
      Location:109 → 216
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    7. XM_039110507.2 → XP_038966435.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/TrEMBL
      F7F4X8
      Conserved Domains (3) summary
      cd00185
      Location:109 → 145
      TNFRSF; CRD1 [structural motif]
      cd10582
      Location:52 → 152
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
      cl22855
      Location:109 → 216
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    8. XM_006239586.5 → XP_006239648.1  tumor necrosis factor receptor superfamily member 14 isoform X4

      UniProtKB/TrEMBL
      A6IUM8, F7F4X8
      Conserved Domains (3) summary
      cd00185
      Location:148 → 211
      TNFRSF; CRD2 [structural motif]
      cd10582
      Location:52 → 152
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
      cl22855
      Location:109 → 216
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    9. XM_063288146.1 → XP_063144216.1  tumor necrosis factor receptor superfamily member 14 isoform X6

    10. XM_039110508.2 → XP_038966436.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      UniProtKB/TrEMBL
      F7F4X8
      Conserved Domains (3) summary
      cd00185
      Location:109 → 145
      TNFRSF; CRD1 [structural motif]
      cd10582
      Location:52 → 152
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
      cl22855
      Location:109 → 216
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    11. XM_039110511.2 → XP_038966439.1  tumor necrosis factor receptor superfamily member 14 isoform X8

      Conserved Domains (2) summary
      cd00185
      Location:72 → 131
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
      cl22855
      Location:4 → 70
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    12. XM_063288144.1 → XP_063144214.1  tumor necrosis factor receptor superfamily member 14 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ATG2
    Nucleotide Protein Strain
    Heading Accession and Version

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