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    PNCK pregnancy up-regulated nonubiquitous CaM kinase [ Homo sapiens (human) ]

    Gene ID: 139728, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PNCKprovided by HGNC
    Official Full Name
    pregnancy up-regulated nonubiquitous CaM kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:13415
    See related
    Ensembl:ENSG00000130822 MIM:300680; AllianceGenome:HGNC:13415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BSTK3; CaMK1b
    Summary
    PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in brain (RPKM 7.4), prostate (RPKM 4.6) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PNCK in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (153669733..153687771, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151943398..151961436, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152935188..152953226, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18a pseudogene 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152932733-152933234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152933235-152933734 Neighboring gene RNA, 7SL, cytoplasmic 687, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21068 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:152936222-152936477 Neighboring gene solute carrier family 6 member 8 Neighboring gene B cell receptor associated protein 31 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152972381-152972881 Neighboring gene Sharpr-MPRA regulatory region 5891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21070

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of Pregnancy Up-regulated Non-ubiquitous Calmodulin Kinase (PNCK) in Hepatocellular Carcinoma. Cho YA, et al. Cancer Genomics Proteomics, 2020 Nov-Dec. PMID 33099476, Free PMC Article
    2. Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process. Deb TB, et al. Breast Cancer Res Treat, 2015 Apr. PMID 25773930
    3. Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma. Wu S, et al. PLoS One, 2013. PMID 23634203, Free PMC Article
    4. Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation. Deb TB, et al. Am J Physiol Cell Physiol, 2008 Aug. PMID 18562482, Free PMC Article
    5. The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer. Gardner HP, et al. Cancer Res, 2000 Oct 1. PMID 11034105

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of Pregnancy Up-regulated Non-ubiquitous Calmodulin Kinase (PNCK) in Hepatocellular Carcinoma.
      Title: Expression of Pregnancy Up-regulated Non-ubiquitous Calmodulin Kinase (PNCK) in Hepatocellular Carcinoma.
    2. Pnck may be a marker of Trastuzumab resistance and possibly a therapeutic target in breast cancer.
      Title: Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process.
    3. the relationship between PNCK and prognosis in clear cell renal cell carcinoma
      Title: Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma.
    4. Pnck induces epidermal growth factor receptor degradation, most likely through perturbation of Hsp90 chaperone activity due to Hsp90 phosphorylation. Epidermal growth factor receptor degradation is coupled to proteasomal degradation of Pnck.
      Title: Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex.
    5. Pnck induces ligand-independent EGFR degradation, and it may represent an attractive therapeutic target in EGFR-regulated oncogenesis.
      Title: Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ50403, FLJ50549, FLJ56451, FLJ59811, MGC45419

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase type 1B
    Names
    caM kinase I beta
    caM kinase IB
    caM-KI beta
    caMKI-beta
    pregnancy up-regulated non-ubiquitously-expressed CaM kinase
    pregnancy upregulated non-ubiquitously expressed CaM kinase
    NP_001034671.3
    NP_001129212.1
    NP_001353904.1
    NP_001353905.1
    NP_001353906.1
    NP_001353907.1
    NP_001353908.1
    NP_001353909.1
    XP_011529409.2
    XP_011529410.1
    XP_011529413.1
    XP_011529414.1
    XP_016884768.1
    XP_024308108.1
    XP_047297792.1
    XP_047297793.1
    XP_047297794.1
    XP_047297795.1
    XP_047297796.1
    XP_054182469.1
    XP_054182470.1
    XP_054182471.1
    XP_054182472.1
    XP_054182473.1
    XP_054182474.1
    XP_054182475.1
    XP_054182476.1
    XP_054182477.1
    XP_054182478.1
    XP_054182479.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039582.3 → NP_001034671.3  calcium/calmodulin-dependent protein kinase type 1B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK296203, AK303746, CF890832, DC383841
      Consensus CDS
      CCDS35503.2
      UniProtKB/Swiss-Prot
      Q6P2M8
      Related
      ENSP00000405950.2, ENST00000447676.6
      Conserved Domains (2) summary
      smart00220
      Location:98 → 353
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14169
      Location:94 → 370
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    2. NM_001135740.2 → NP_001129212.1  calcium/calmodulin-dependent protein kinase type 1B isoform b

      See identical proteins and their annotated locations for NP_001129212.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK303746, CF890832
      Consensus CDS
      CCDS48189.1
      UniProtKB/Swiss-Prot
      Q6P2M8
      Related
      ENSP00000359164.4, ENST00000370145.8
      Conserved Domains (2) summary
      smart00220
      Location:32 → 287
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14169
      Location:28 → 304
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    3. NM_001366975.1 → NP_001353904.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 4-8, encodes isoform c.
      Source sequence(s)
      U52111
      Consensus CDS
      CCDS94698.1
      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    4. NM_001366976.1 → NP_001353905.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 5-8, encodes isoform c.
      Source sequence(s)
      U52111
      Consensus CDS
      CCDS94698.1
      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    5. NM_001366977.1 → NP_001353906.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 3, 6, 7, and 8, encodes isoform c.
      Source sequence(s)
      U52111
      Consensus CDS
      CCDS94698.1
      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
      Related
      ENSP00000340586.4, ENST00000340888.8
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    6. NM_001366978.1 → NP_001353907.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 3-5, 7, and 8, encodes isoform c.
      Source sequence(s)
      U52111
      Consensus CDS
      CCDS94698.1
      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    7. NM_001366979.1 → NP_001353908.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 3-6 and 8, encodes isoform c.
      Source sequence(s)
      U52111
      Consensus CDS
      CCDS94698.1
      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    8. NM_001366980.1 → NP_001353909.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 3-7, encodes isoform c.
      Source sequence(s)
      U52111
      Consensus CDS
      CCDS94698.1
      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
      Related
      ENSP00000359169.1, ENST00000370150.5
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      153669733..153687771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531107.3 → XP_011529409.2  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    2. XM_047441836.1 → XP_047297792.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

    3. XM_047441838.1 → XP_047297794.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

    4. XM_047441837.1 → XP_047297793.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
      Related
      ENST00000466074.5

    5. XM_047441839.1 → XP_047297795.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

    6. XM_024452340.2 → XP_024308108.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    7. XM_011531108.3 → XP_011529410.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

      See identical proteins and their annotated locations for XP_011529410.1

      Conserved Domains (2) summary
      smart00220
      Location:33 → 288
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14169
      Location:29 → 305
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    8. XM_011531112.3 → XP_011529414.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      See identical proteins and their annotated locations for XP_011529414.1

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
      Related
      ENSP00000359161.1, ENST00000370142.5
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    9. XM_011531111.3 → XP_011529413.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      See identical proteins and their annotated locations for XP_011529413.1

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    10. XM_017029279.2 → XP_016884768.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    11. XM_047441840.1 → XP_047297796.1  calcium/calmodulin-dependent protein kinase type 1B isoform X3

      UniProtKB/TrEMBL
      B4DJP1
      Related
      ENST00000489536.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      151943398..151961436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326503.1 → XP_054182478.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

    2. XM_054326496.1 → XP_054182471.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

    3. XM_054326499.1 → XP_054182474.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

    4. XM_054326498.1 → XP_054182473.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

    5. XM_054326501.1 → XP_054182476.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

    6. XM_054326497.1 → XP_054182472.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

    7. XM_054326494.1 → XP_054182469.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

    8. XM_054326500.1 → XP_054182475.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

    9. XM_054326495.1 → XP_054182470.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

    10. XM_054326502.1 → XP_054182477.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

    11. XM_054326504.1 → XP_054182479.1  calcium/calmodulin-dependent protein kinase type 1B isoform X3

      UniProtKB/TrEMBL
      B4DJP1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198452.1: Suppressed sequence

      Description
      NM_198452.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P2M8.2 GenPept UniProtKB/Swiss-Prot:Q6P2M8

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