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    ZNF777 zinc finger protein 777 [ Homo sapiens (human) ]

    Gene ID: 27153, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF777provided by HGNC
    Official Full Name
    zinc finger protein 777provided by HGNC
    Primary source
    HGNC:HGNC:22213
    See related
    Ensembl:ENSG00000196453 MIM:619298; AllianceGenome:HGNC:22213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of cell population proliferation; and protein heterooligomerization. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 4.5), brain (RPKM 4.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF777 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149431363..149461062, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150613213..150642913, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149128454..149158153, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375559 Neighboring gene uncharacterized LOC101928733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26814 Neighboring gene tRNA-Cys (anticodon GCA) 11-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149118879-149119378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18759 Neighboring gene zinc finger protein 746 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:149191224-149192423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149193218-149194161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26816 Neighboring gene tRNA-Cys (anticodon GCA) 16-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of zinc-finger protein 777 (ZNF777) inhibits proliferation at low cell density through down-regulation of FAM129A. Yuki R, et al. J Cell Biochem, 2015 Jun. PMID 25560148
    2. DUF3669, a "domain of unknown function" within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression. Al Chiblak M, et al. BMC Mol Cell Biol, 2019 Dec 19. PMID 31856708, Free PMC Article
    3. A GO catalogue of human DNA-binding transcription factors. Lovering RC, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34673265
    4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462
    5. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Connaughton DM, et al. Am J Hum Genet, 2020 Oct 1. PMID 32891193, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1285

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein heterooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 777

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015694.3 → NP_056509.2  zinc finger protein 777

      See identical proteins and their annotated locations for NP_056509.2

      Status: VALIDATED

      Source sequence(s)
      AB033111, AC073314, BC023985, BX444270, DR763452
      Consensus CDS
      CCDS43675.1
      UniProtKB/Swiss-Prot
      Q8N2R2, Q8N659, Q9ULD5
      Related
      ENSP00000247930.4, ENST00000247930.5
      Conserved Domains (7) summary
      smart00349
      Location:285 → 343
      KRAB; krueppel associated box
      COG5048
      Location:640 → 826
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK10263
      Location:6 → 186
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:696 → 716
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:669 → 686
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:546 → 568
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:199 → 255
      DUF3669; Zinc finger protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      149431363..149461062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005249980.4 → XP_005250037.1  zinc finger protein 777 isoform X1

      Conserved Domains (8) summary
      cd07765
      Location:329 → 368
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:329 → 387
      KRAB; krueppel associated box
      COG5048
      Location:684 → 870
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:740 → 760
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:713 → 730
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:738 → 760
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:752 → 776
      zf-H2C2_2; Zinc-finger double domain
      pfam14353
      Location:681 → 730
      CpXC; CpXC protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      150613213..150642913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357906.1 → XP_054213881.1  zinc finger protein 777 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULD5.3 GenPept UniProtKB/Swiss-Prot:Q9ULD5

    Gene LinkOut

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