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    OR2V1 olfactory receptor family 2 subfamily V member 1 [ Homo sapiens (human) ]

    Gene ID: 26693, updated on 10-Dec-2024

    Summary

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    Official Symbol
    OR2V1provided by HGNC
    Official Full Name
    olfactory receptor family 2 subfamily V member 1provided by HGNC
    Primary source
    HGNC:HGNC:8280
    See related
    Ensembl:ENSG00000185372 AllianceGenome:HGNC:8280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR2V1P; OST265
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Orthologs
    all
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    Genomic context

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    See OR2V1 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (181123122..181131169, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181683156..181691193, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180550122..180558169, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene tRNA-Val (anticodon CAC) 1-3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180531361-180531862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180531863-180532362 Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 4 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180556955-180557456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180565055-180565554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180574489-180575211 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180577953-180578454 Neighboring gene olfactory receptor family 2 subfamily V member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180586450-180587206 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180587207-180587962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23778 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:180588627-180588969 Neighboring gene Sharpr-MPRA regulatory region 11855 Neighboring gene tRNA-Val (anticodon AAC) 1-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. Barnes IHA, et al. BMC Genomics, 2020 Mar 3. PMID 32126975, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 2V1
    Names
    olfactory receptor, family 2, subfamily V, member 1 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258283.2 → NP_001245212.1  olfactory receptor 2V1

      See identical proteins and their annotated locations for NP_001245212.1

      Status: VALIDATED

      Source sequence(s)
      AC008620
      Consensus CDS
      CCDS58992.1
      UniProtKB/Swiss-Prot
      Q8NHB1
      UniProtKB/TrEMBL
      A0A126GWQ1
      Related
      ENSP00000492946.1, ENST00000641551.1
      Conserved Domains (2) summary
      pfam00001
      Location:42 → 291
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:35 → 306
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      181123122..181131169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      181683156..181691193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_004137.3: Suppressed sequence

      Description
      NG_004137.3: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NHB1.2 GenPept UniProtKB/Swiss-Prot:Q8NHB1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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