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    CDCA8 cell division cycle associated 8 [ Homo sapiens (human) ]

    Gene ID: 55143, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CDCA8provided by HGNC
    Official Full Name
    cell division cycle associated 8provided by HGNC
    Primary source
    HGNC:HGNC:14629
    See related
    Ensembl:ENSG00000134690 MIM:609977; AllianceGenome:HGNC:14629
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BOR; DasraB; MESRGP; BOREALIN
    Summary
    This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
    Expression
    Biased expression in testis (RPKM 14.3), bone marrow (RPKM 12.4) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDCA8 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (37692516..37709719)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (37557243..37574423)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38158188..38175391)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1490 Neighboring gene R-spondin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38096333-38096846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38098855-38099382 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38099911-38100438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38100439-38100965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38126219-38126852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38128815-38129348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38129349-38129881 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38132271-38132990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38156929-38157439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38157440-38157949 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:38157950-38158460 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:38158461-38158969 Neighboring gene AFG2 interacting ribosome maturation factor Neighboring gene MPRA-validated peak183 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38191191-38191692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38191693-38192192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38192280-38192780 Neighboring gene EPH receptor A10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38192781-38193281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38201025-38201524 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 677 Neighboring gene uncharacterized LOC105378650

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MiR-133a-3p inhibits the malignant progression of oesophageal cancer by targeting CDCA8. Wang X, et al. J Biochem, 2022 Jan 7. PMID 34117764
    2. Borealin-nucleosome interaction secures chromosome association of the chromosomal passenger complex. Abad MA, et al. J Cell Biol, 2019 Dec 2. PMID 31570499, Free PMC Article
    3. CDCA8 is a key mediator of estrogen-stimulated cell proliferation in breast cancer cells. Bu Y, et al. Gene, 2019 Jun 30. PMID 30953709
    4. Overexpression of CDCA8 promotes the malignant progression of cutaneous melanoma and leads to poor prognosis. Ci C, et al. Int J Mol Med, 2019 Jan. PMID 30431060, Free PMC Article
    5. Regulators CDCA8 as potential targets and biomarkers for the prognosis of human skin cutaneous melanoma. Guo R, et al. J Cosmet Dermatol, 2022 Nov. PMID 35575979

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDCA8 Facilitates Tumor Proliferation and Predicts a Poor Prognosis in Hepatocellular Carcinoma.
      Title: CDCA8 Facilitates Tumor Proliferation and Predicts a Poor Prognosis in Hepatocellular Carcinoma.
    2. CDCA8 promotes bladder cancer survival by stabilizing HIF1alpha expression under hypoxia.
      Title: CDCA8 promotes bladder cancer survival by stabilizing HIF1α expression under hypoxia.
    3. Cell division cycle-associated 8 is a prognostic biomarker related to immune invasion in hepatocellular carcinoma.
      Title: Cell division cycle-associated 8 is a prognostic biomarker related to immune invasion in hepatocellular carcinoma.
    4. A 1-kb human CDCA8 promoter directs the spermatogonia-specific luciferase expression in adult testis.
      Title: A 1-kb human CDCA8 promoter directs the spermatogonia-specific luciferase expression in adult testis.
    5. Regulators CDCA8 as potential targets and biomarkers for the prognosis of human skin cutaneous melanoma.
      Title: Regulators CDCA8 as potential targets and biomarkers for the prognosis of human skin cutaneous melanoma.
    6. Methylation-dependent and -independent roles of EZH2 synergize in CDCA8 activation in prostate cancer.
      Title: Methylation-dependent and -independent roles of EZH2 synergize in CDCA8 activation in prostate cancer.
    7. MiR-133a-3p inhibits the malignant progression of oesophageal cancer by targeting CDCA8.
      Title: MiR-133a-3p inhibits the malignant progression of oesophageal cancer by targeting CDCA8.
    8. Identification of CDCA8, DSN1 and BIRC5 in Regulating Cell Cycle and Apoptosis in Osteosarcoma Using Bioinformatics and Cell Biology.
      Title: Identification of CDCA8, DSN1 and BIRC5 in Regulating Cell Cycle and Apoptosis in Osteosarcoma Using Bioinformatics and Cell Biology.
    9. Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma.
      Title: Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma.
    10. Development and validation of hub genes for lymph node metastasis in patients with prostate cancer.
      Title: Development and validation of hub genes for lymph node metastasis in patients with prostate cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10468, FLJ12042

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle midzone assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of mitotic sister chromatid separation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromocenter IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromosome passenger complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    borealin
    Names
    Dasra B
    cell division cycle-associated protein 8
    dasra-B
    hDasra-B
    pluripotent embryonic stem cell-related gene 3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256875.2 → NP_001243804.1  borealin

      See identical proteins and their annotated locations for NP_001243804.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC001651, BC008079
      Consensus CDS
      CCDS424.1
      UniProtKB/Swiss-Prot
      D3DPT4, Q53HL2, Q53HN1, Q96AM3, Q9NVW5
      UniProtKB/TrEMBL
      A8K7A2
      Related
      ENSP00000362146.1, ENST00000373055.6
      Conserved Domains (2) summary
      pfam10444
      Location:22 → 76
      Nbl1_Borealin_N; Nbl1 / Borealin N terminal
      pfam10512
      Location:163 → 275
      Borealin; Cell division cycle-associated protein 8

    2. NM_018101.4 → NP_060571.1  borealin

      See identical proteins and their annotated locations for NP_060571.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY508815, BC008079
      Consensus CDS
      CCDS424.1
      UniProtKB/Swiss-Prot
      D3DPT4, Q53HL2, Q53HN1, Q96AM3, Q9NVW5
      UniProtKB/TrEMBL
      A8K7A2
      Related
      ENSP00000316121.2, ENST00000327331.2
      Conserved Domains (2) summary
      pfam10444
      Location:22 → 76
      Nbl1_Borealin_N; Nbl1 / Borealin N terminal
      pfam10512
      Location:163 → 275
      Borealin; Cell division cycle-associated protein 8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      37692516..37709719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      37557243..37574423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53HL2.2 GenPept UniProtKB/Swiss-Prot:Q53HL2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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