Ddx1 Dead-box-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ddx1provided by FlyBase
Official Full Name: Dead-box-1provided by FlyBase
Primary source: FLYBASE:FBgn0015075
Locus tag: Dmel_CG9054
See related: AllianceGenome:FB:FBgn0015075
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-79E; CG9054; Dbp79E; DDX1; DmDDX1; Dmel\CG9054; DmRH12
Summary: Predicted to enable several functions, including helicase activity; poly(A) binding activity; and transcription coregulator activity. Involved in several processes, including embryonic development via the syncytial blastoderm; spermatogenesis; and tRNA processing. Predicted to be located in nucleus. Predicted to be part of tRNA-splicing ligase complex. Is expressed in adult head and organism. Orthologous to human DDX1 (DEAD-box helicase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (22263369..22266017)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (22256469..22259117)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

These data suggest a role for Drosophila Ddx1 in stress-induced regulation of splicing.
Title: Loss of the Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis.
DEAD-box protein Bel has evolutionarily conserved roles in fertility and development.
Title: Belle is a Drosophila DEAD-box protein required for viability and in the germ line.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA/RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(A) binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic development via the syncytial blastoderm	IEP Inferred from Expression Pattern more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of tRNA-splicing ligase complex	ISS Inferred from Sequence or Structural Similarity more info

NP_524212.2

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The following sections contain reference sequences that belong to a specific genome build. Explain