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    IntS1 Integrator 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37840, updated on 27-Dec-2024

    Summary

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    Official Symbol
    IntS1provided by FlyBase
    Official Full Name
    Integrator 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034964
    Locus tag
    Dmel_CG3173
    See related
    AllianceGenome:FB:FBgn0034964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3173; Dmel\CG3173; Int1; intS1
    Summary
    Involved in positive regulation of neuron differentiation and snRNA 3'-end processing. Part of integrator complex. Is active in nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies. Orthologous to human INTS1 (integrator complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See IntS1 in Genome Data Viewer
    Location:
    60B5-60B5; 2-106 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24037943..24044458)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19925466..19931981)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene MAN1 Neighboring gene CCR4-NOT transcription complex subunit 11 Neighboring gene twinstar Neighboring gene gamma Soluble NSF attachment protein 1 Neighboring gene seizure Neighboring gene pickpocket 29 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes. Elrod ND, et al. Mol Cell, 2019 Dec 5. PMID 31809743, Free PMC Article
    2. Inositol hexakisphosphate is required for Integrator function. Lin MH, et al. Nat Commun, 2022 Sep 30. PMID 36180473, Free PMC Article
    3. Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus. Song Z, et al. Sci China Life Sci, 2021 May. PMID 32815066
    4. The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells. Zhang Y, et al. Cell Rep, 2019 Apr 23. PMID 31018143
    5. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in U2 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U2 snRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrator 1
    Names
    CG3173-PA
    IntS1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24037943..24044458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138031.3 → NP_611875.1  integrator 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611875.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IGA9, Q9W1C5
      Related
      FBpp0072077
      Conserved Domains (1) summary
      pfam12432
      Location:327 → 407
      DUF3677; Protein of unknown function (DUF3677)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1C5.2 Q9W1C5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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