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    Usp5 Ubiquitin specific protease 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38375, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Usp5provided by FlyBase
    Official Full Name
    Ubiquitin specific protease 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0035402
    Locus tag
    Dmel_CG12082
    See related
    AllianceGenome:FB:FBgn0035402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1208; CG12082; Dmel\CG12082; DmUsp5; DmUSP5; leon; Q9VZU7; usp5; USP5
    Summary
    Enables K48-linked deubiquitinase activity. Involved in several processes, including free ubiquitin chain depolymerization; negative regulation of JNK cascade; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human USP13 (ubiquitin specific peptidase 13) and USP5 (ubiquitin specific peptidase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Usp5 in Genome Data Viewer
    Location:
    63B6-63B7; 3-6 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3145405..3148358, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3145405..3148358, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45819 Neighboring gene ALG2, alpha-1,3/1,6-mannosyltransferase Neighboring gene BTB-protein-VII Neighboring gene NADH dehydrogenase (ubiquinone) 30 kDa subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental and tissue specific changes of ubiquitin forms in Drosophila melanogaster. Nagy Á, et al. PLoS One, 2018. PMID 30543682, Free PMC Article
    2. The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development. Ling X, et al. FEBS Lett, 2017 Mar. PMID 28140449
    3. Drosophila USP5 controls the activation of apoptosis and the Jun N-terminal kinase pathway during eye development. Fan X, et al. PLoS One, 2014. PMID 24643212, Free PMC Article
    4. Role of the deubiquitylating enzyme DmUsp5 in coupling ubiquitin equilibrium to development and apoptosis in Drosophila melanogaster. Kovács L, et al. PLoS One, 2015. PMID 25806519, Free PMC Article
    5. fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila. Yagi Y, et al. Genes Cells, 2013 Nov. PMID 23919485

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster.
      Title: Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster.
    2. Thus, the deubiquitinase Leon maintains ubiquitin homeostasis and proper Ubiquilin levels, preventing postsynaptic proteins from accumulation to confine postsynaptic growth.
      Title: USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin.
    3. Loss of Usp5 results in upregulation of Notch signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
      Title: The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development.
    4. work indicates that a primary physiological role of USP5 is not to recycle monoubiquitin for reutilization, but that it may involve disassembly of conjugated ubiquitin to maintain proteasome function.
      Title: USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila.
    5. USP5 regulates ubiquitin homeostasis during Drosophila development.
      Title: The deubiquitinase Leon/USP5 regulates ubiquitin homeostasis during Drosophila development.
    6. Drosophila USP5 deletion phenotypes are caused by the activation of apoptosis and JNK pathway.
      Title: Drosophila USP5 controls the activation of apoptosis and the Jun N-terminal kinase pathway during eye development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in free ubiquitin chain depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteasome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin specific protease 5
    Names
    CG12082-PA
    CG12082-PB
    CG12082-PC
    Usp5-PA
    Usp5-PB
    Usp5-PC
    isopeptidase T
    NP_001246589.1
    NP_001334708.1
    NP_647773.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3145405..3148358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259660.2 → NP_001246589.1  ubiquitin specific protease 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246589.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZU7
      Conserved Domains (5) summary
      COG5207
      Location:24 → 825
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02658
      Location:333 → 823
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14294
      Location:631 → 674
      UBA1_UBP5_like; UBA1 domain found in ubiquitin carboxyl-terminal hydrolase UBP5, UBP13 and similar proteins
      cd14386
      Location:696 → 737
      UBA2_UBP5; UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5)
      pfam02148
      Location:204 → 278
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    2. NM_139516.1 → NP_647773.1  ubiquitin specific protease 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZU7
      Related
      FBpp0072976, FBtr0073114
      Conserved Domains (5) summary
      COG5207
      Location:24 → 825
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02658
      Location:333 → 823
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14294
      Location:631 → 674
      UBA1_UBP5_like; UBA1 domain found in ubiquitin carboxyl-terminal hydrolase UBP5, UBP13 and similar proteins
      cd14386
      Location:696 → 737
      UBA2_UBP5; UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5)
      pfam02148
      Location:204 → 278
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    3. NM_001347744.1 → NP_001334708.1  ubiquitin specific protease 5, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZU7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZU7 Q9VZU7

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