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    Sec23 Secretory 23 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40694, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Sec23provided by FlyBase
    Official Full Name
    Secretory 23provided by FlyBase
    Primary source
    FLYBASE:FBgn0262125
    Locus tag
    Dmel_CG1250
    See related
    AllianceGenome:FB:FBgn0262125
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1250; COPII; dar2; Dmel\CG1250; dsec23; dSec23; dsec23p; dSec23p; hau; Hau; sec23; SEC23; Sec23A; Sec23p
    Summary
    Predicted to enable GTPase activator activity. Involved in several processes, including chitin-based larval cuticle pattern formation; protein localization to cell surface; and secretion by cell. Acts upstream of with a positive effect on chitin-based cuticle development and lumen formation, open tracheal system. Located in Golgi stack and endoplasmic reticulum exit site. Part of COPII vesicle coat. Is expressed in several structures, including adult head; embryonic proventriculus inner layer; gland; gut section; and mesoderm. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Orthologous to several human genes including SEC23B (SEC23 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sec23 in Genome Data Viewer
    Location:
    83B7-83B8; 3-47.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5649065..5652629)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1474787..1478351)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Metastasis associated 1-like Neighboring gene ethanol sensitive with low memory Neighboring gene Mediator complex subunit 27 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila ataxin-2 gene encodes two differentially expressed isoforms and its function in larval fat body is crucial for development of peripheral tissues. Vianna MC, et al. FEBS Open Bio, 2016 Nov. PMID 27833845, Free PMC Article
    2. Trafficking along the secretory pathway in Drosophila cell line and tissues: a light and electron microscopy approach. Zacharogianni M, et al. Methods Cell Biol, 2013. PMID 24295299
    3. The cis-Golgi Drosophila GMAP has a role in anterograde transport and Golgi organization in vivo, similar to its mammalian ortholog in tissue culture cells. Friggi-Grelin F, et al. Eur J Cell Biol, 2006 Nov. PMID 16904228
    4. A Conserved Di-Basic Motif of Drosophila Crumbs Contributes to Efficient ER Export. Kumichel A, et al. Traffic, 2015 Jun. PMID 25753515, Free PMC Article
    5. Ferritin Is Required in Multiple Tissues during Drosophila melanogaster Development. González-Morales N, et al. PLoS One, 2015. PMID 26192321, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Essential Role of COPII Proteins in Maintaining the Contractile Ring Anchoring to the Plasma Membrane during Cytokinesis in Drosophila Male Meiosis.
      Title: Essential Role of COPII Proteins in Maintaining the Contractile Ring Anchoring to the Plasma Membrane during Cytokinesis in Drosophila Male Meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle budding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_positive_effect chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based larval cuticle pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix constituent secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in larval chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect lumen formation, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of COPII vesicle coating ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COPII vesicle coat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of COPII vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secretory 23
    Names
    CG1250-PA
    CG1250-PB
    CG1250-PD
    CG1250-PE
    CG1250-PF
    CG1250-PG
    CG1250-PH
    Sec23 ortholog
    Sec23-PA
    Sec23-PB
    Sec23-PD
    Sec23-PE
    Sec23-PF
    Sec23-PG
    Sec23-PH
    coat protein II
    dendritic arbor reduction 2
    haunted
    sec23

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5649065..5652629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260005.2 → NP_001246934.1  secretory 23, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246934.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6T4, Q8IGT0
      Conserved Domains (6) summary
      cd11287
      Location:618 → 738
      Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
      PLN00162
      Location:12 → 778
      PLN00162; transport protein sec23; Provisional
      cd01478
      Location:126 → 396
      Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:58 → 97
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:530 → 623
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:409 → 512
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    2. NM_169089.4 → NP_730979.1  secretory 23, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730979.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGT0, Q9VNF8
      Related
      FBpp0078359
      Conserved Domains (6) summary
      cd11287
      Location:618 → 738
      Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
      PLN00162
      Location:12 → 771
      PLN00162; transport protein sec23; Provisional
      cd01478
      Location:126 → 396
      Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:58 → 97
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:530 → 623
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:409 → 512
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    3. NM_169088.2 → NP_730978.1  secretory 23, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730978.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGT0, Q9VNF8
      Related
      FBpp0078360
      Conserved Domains (6) summary
      cd11287
      Location:618 → 738
      Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
      PLN00162
      Location:12 → 771
      PLN00162; transport protein sec23; Provisional
      cd01478
      Location:126 → 396
      Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:58 → 97
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:530 → 623
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:409 → 512
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    4. NM_001260003.1 → NP_001246932.1  secretory 23, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246932.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K5Z8, Q8IGT0
      Conserved Domains (6) summary
      cd11287
      Location:618 → 738
      Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
      PLN00162
      Location:12 → 779
      PLN00162; transport protein sec23; Provisional
      cd01478
      Location:126 → 396
      Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:58 → 97
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:530 → 623
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:409 → 512
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    5. NM_001260004.1 → NP_001246933.1  secretory 23, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6T4, Q8IGT0
      Conserved Domains (6) summary
      cd11287
      Location:618 → 738
      Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
      PLN00162
      Location:12 → 778
      PLN00162; transport protein sec23; Provisional
      cd01478
      Location:126 → 396
      Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:58 → 97
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:530 → 623
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:409 → 512
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    6. NM_001300255.1 → NP_001287184.1  secretory 23, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287184.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGT0, Q9VNF8
      Conserved Domains (6) summary
      cd11287
      Location:618 → 738
      Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
      PLN00162
      Location:12 → 771
      PLN00162; transport protein sec23; Provisional
      cd01478
      Location:126 → 396
      Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:58 → 97
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:530 → 623
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:409 → 512
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    7. NM_001275365.1 → NP_001262294.1  secretory 23, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262294.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGT0, Q9VNF8
      Conserved Domains (6) summary
      cd11287
      Location:618 → 738
      Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
      PLN00162
      Location:12 → 771
      PLN00162; transport protein sec23; Provisional
      cd01478
      Location:126 → 396
      Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:58 → 97
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:530 → 623
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:409 → 512
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K5Z8 A0A0B4K5Z8
    A0A0B4K6T4 A0A0B4K6T4
    Q8IGT0 Q8IGT0
    Q95TD2 Q95TD2
    Q9NFN9 Q9NFN9
    Q9VNF8 Q9VNF8

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