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    nSMase neutral sphingomyelinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38396, updated on 17-Dec-2024

    Summary

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    Official Symbol
    nSMaseprovided by FlyBase
    Official Full Name
    neutral sphingomyelinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035421
    Locus tag
    Dmel_CG12034
    See related
    AllianceGenome:FB:FBgn0035421
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12034; Dmel\CG12034; nsmase
    Summary
    Predicted to enable sphingomyelin phosphodiesterase activity. Predicted to be involved in ceramide biosynthetic process; sphingolipid catabolic process; and sphingomyelin metabolic process. Predicted to be active in caveola and endoplasmic reticulum. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and mesoderm. Orthologous to human SMPD2 (sphingomyelin phosphodiesterase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nSMase in Genome Data Viewer
    Location:
    63B14-63B14; 3-6 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3219156..3220925)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3219156..3220925)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene gryzun Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hobbit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein L28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles. Jewett KA, et al. PLoS Genet, 2021 Feb. PMID 33539341, Free PMC Article
    2. PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability. Fevga C, et al. Brain, 2023 Apr 19. PMID 36073231, Free PMC Article
    3. Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants. Hebbar S, et al. Sci Rep, 2015 Dec 7. PMID 26639035, Free PMC Article
    4. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila. Chen X, et al. Natl Sci Rev, 2022 Dec. PMID 36713590, Free PMC Article
    5. Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. Renault AD, et al. Mech Dev, 2002 Dec. PMID 14516700

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neutral sphingomyelin phosphodiesterase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables sphingomyelin phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingomyelin phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingomyelin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in caveola IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neutral sphingomyelinase
    Names
    CG12034-PA
    nSMase-PA
    neutral-sphingomyelinase
    NP_647790.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3219156..3220925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139533.4 → NP_647790.1  neutral sphingomyelinase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647790.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961B4, Q9VZS6
      Related
      FBpp0072907
      Conserved Domains (1) summary
      cl00490
      Location:12 → 267
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZS6.2 Q9VZS6

    Gene LinkOut

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