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    CG5235 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5235provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036565
    Locus tag
    Dmel_CG5235
    See related
    AllianceGenome:FB:FBgn0036565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5235
    Summary
    Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Predicted to be active in extracellular space and secretory granule membrane. Is expressed in several structures, including antennal primordium; central brain primordium; embryonic central brain neurons; ganglia; and head epidermis primordium. Orthologous to human MOXD1 (monooxygenase DBH like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5235 in Genome Data Viewer
    Location:
    72D4-72D5; 3-44 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16087627..16090392, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16080727..16083492, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Taspase 1 Neighboring gene Chloride channel-c Neighboring gene uncharacterized protein Neighboring gene ATP synthase, beta subunit-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DOMON: an ancient extracellular domain in dopamine beta-monooxygenase and other proteins. Aravind L. Trends Biochem Sci, 2001 Sep. PMID 11551777
    2. Characterizing the genetic basis of copper toxicity in Drosophila reveals a complex pattern of allelic, regulatory, and behavioral variation. Everman ER, et al. Genetics, 2021 Mar 3. PMID 33683361, Free PMC Article
    3. Gene expression variation underlying tissue-specific responses to copper stress in Drosophila melanogaster. Everman ER, et al. G3 (Bethesda), 2024 Mar 6. PMID 38262701, Free PMC Article
    4. Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen. Azad P, et al. G3 (Bethesda), 2012 Oct. PMID 23050227, Free PMC Article
    5. Identification of conserved transcriptome features between humans and Drosophila in the aging brain utilizing machine learning on combined data from the NIH Sequence Read Archive. Webb JL, et al. PLoS One, 2021. PMID 34379632, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dopamine beta-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dopamine beta-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dopamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in norepinephrine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in octopamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in secretory granule membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5235-PA
    CG5235-PB
    NP_001261921.1
    NP_648833.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16087627..16090392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140576.4 → NP_648833.1  uncharacterized protein Dmel_CG5235, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648833.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYE9, Q9VUY0
      UniProtKB/TrEMBL
      M9PFT8
      Related
      FBpp0075252
      Conserved Domains (3) summary
      pfam01082
      Location:214 → 354
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03351
      Location:54 → 174
      DOMON; DOMON domain
      pfam03712
      Location:374 → 529
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    2. NM_001274992.2 → NP_001261921.1  uncharacterized protein Dmel_CG5235, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261921.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYE9, Q9VUY0
      UniProtKB/TrEMBL
      M9PFT8
      Conserved Domains (3) summary
      pfam01082
      Location:214 → 354
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03351
      Location:54 → 174
      DOMON; DOMON domain
      pfam03712
      Location:374 → 529
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFT8 M9PFT8
    Q9VUY0.2 Q9VUY0

    Gene LinkOut

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