IL11 interleukin 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL11provided by HGNC
Official Full Name: interleukin 11provided by HGNC
Primary source: HGNC:HGNC:5966
See related: Ensembl:ENSG00000095752 MIM:147681; AllianceGenome:HGNC:5966
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AGIF; IL-11
Summary: The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Expression: Biased expression in endometrium (RPKM 2.0), appendix (RPKM 1.5) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.42

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (55364382..55370463, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (58459867..58465950, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (55875750..55881831, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration.
Title: Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration.
Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina.
Title: Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina.
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
Title: Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis.
Title: Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis.
Serum levels of IL-9 and IL-11 serve as predictors for the occurrence of early neurologic deterioration in patients with cerebral infarction.
Title: Serum levels of IL-9 and IL-11 serve as predictors for the occurrence of early neurologic deterioration in patients with cerebral infarction.
Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.
Title: Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.
IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFbeta.
Title: IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.
Understanding interleukin 11 as a disease gene and therapeutic target.
Title: Understanding interleukin 11 as a disease gene and therapeutic target.
m[6]A modification of AC026356.1 facilitates hepatocellular carcinoma progression by regulating the IGF2BP1-IL11 axis.
Title: m(6)A modification of AC026356.1 facilitates hepatocellular carcinoma progression by regulating the IGF2BP1-IL11 axis.
Biophysical insight into protein-protein interactions in the Interleukin-11/Interleukin-11Ralpha/glycoprotein 130 signaling complex.
Title: Biophysical insight into protein-protein interactions in the Interleukin-11/Interleukin-11Rα/glycoprotein 130 signaling complex.

Submit: New GeneRIF Correction See all GeneRIFs (184)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	IL-11 inhibits HIV-1 gp120-mediated downregulation of IFN-gamma in human NK cells	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of interleukin 11 gene (IL11) in mammary epithelial cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

D1S1431 (e-PCR)
- UniSTS:149627

D19S1168 (e-PCR)
- UniSTS:4220

RH36905 (e-PCR)
- UniSTS:87932

STS-W47396 (e-PCR)
- UniSTS:32188

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-11 receptor binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in interleukin-11-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in megakaryocyte differentiation	NAS Non-traceable Author Statement more info	PubMed
NOT involved_in negative regulation of endothelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in regulation of complement-dependent cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-11

Names: adipogenesis inhibitory factor; oprelvekin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000641.4 → NP_000632.1 interleukin-11 isoform 1 precursor

See identical proteins and their annotated locations for NP_000632.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC020922, AK315294, BF055151

Consensus CDS

CCDS12923.1

UniProtKB/Swiss-Prot

B4DQV5, P20809, Q96EB4

UniProtKB/TrEMBL

A8K3F7

Related

ENSP00000264563.1, ENST00000264563.7

Conserved Domains (1) summary

pfam07400
Location:23 → 199

IL11; Interleukin 11
NM_001267718.2 → NP_001254647.1 interleukin-11 isoform 2

See identical proteins and their annotated locations for NP_001254647.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' coding region, which results in a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC020922, AK298973, BF055151

Consensus CDS

CCDS59423.1

UniProtKB/Swiss-Prot

P20809

Related

ENSP00000465705.1, ENST00000590625.5

Conserved Domains (1) summary

pfam07400
Location:1 → 120

IL11; Interleukin 11