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    SERPINE2 serpin family E member 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707121, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SERPINE2provided by VGNC
    Official Full Name
    serpin family E member 2provided by VGNC
    Primary source
    VGNC:VGNC:77369
    Locus tag
    EGK_04851
    See related
    Ensembl:ENSMMUG00000006161
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    PN-1; SERPINE1
    Orthologs
    human mouse all
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    Genomic context

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    See SERPINE2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (111427193..111492798, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (106247382..106312941, complement)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene WD repeat and FYVE domain containing 1 Neighboring gene mitochondrial ribosomal protein L44 Neighboring gene ubiquitin carboxyl-terminal hydrolase 21 pseudogene Neighboring gene family with sequence similarity 124 member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of prostasin serine protease and protease nexin-1 (PN-1) in rhesus monkey ovary during menstrual cycle and early pregnancy. Zhang H, et al. J Histochem Cytochem, 2007 Dec. PMID 17827166
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prostasin may be involved in follicular development, ovulation, and CL formation, whereas PN-1 may be present to regulate the proteolysis in these processes.[prostasin; protease nexin-1]
      Title: Expression of prostasin serine protease and protease nexin-1 (PN-1) in rhesus monkey ovary during menstrual cycle and early pregnancy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of plasminogen activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glia-derived nexin
    Names
    protease nexin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      111427193..111492798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015111172.2 → XP_014966658.1  glia-derived nexin

      UniProtKB/TrEMBL
      A0A5F7ZZ86, A0A8J8YSM5, F7HSW0, G7N922
      Related
      ENSMMUP00000070980.1, ENSMMUT00000081173.1
      Conserved Domains (1) summary
      cd02051
      Location:22 → 397
      PAI-1_nexin-1; Plasminogen activator inhibitor-1_like. Plasminogen activator inhibitor-1 (PAI-1) is the primary, fast-acting inhibitor of plasminogen activators. It is often bound to vitronectin, an abundant component of the extracellular matrix in many tissues. ...
    Nucleotide Protein
    Heading Accession and Version

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