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    PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 709959, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PIK3CAprovided by VGNC
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:75995
    See related
    Ensembl:ENSMMUG00000005188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See PIK3CA in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (84324191..84360336)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (114041160..114077927, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene zinc finger matrin-type 3 Neighboring gene small nucleolar RNA SNORA25 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 3 Neighboring gene leucine-rich repeat flightless-interacting protein 1 pseudogene Neighboring gene zinc finger protein 639

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IB IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Names
    phosphoinositide-3-kinase, catalytic, alpha polypeptide
    NP_001247597.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260668.1 → NP_001247597.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

      See identical proteins and their annotated locations for NP_001247597.1

      Status: PROVISIONAL

      Source sequence(s)
      JU476009
      UniProtKB/TrEMBL
      F7CTS2, G7MJ92, H9FVU5
      Related
      ENSMMUP00000006866.4, ENSMMUT00000007307.4
      Conserved Domains (5) summary
      cd08398
      Location:325 → 484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:173 → 292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525 → 696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:695 → 1064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      84324191..84360336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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