U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CHN2 chimerin 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 697231, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CHN2provided by VGNC
    Official Full Name
    chimerin 2provided by VGNC
    Primary source
    VGNC:VGNC:80861
    See related
    Ensembl:ENSMMUG00000008329
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CHN2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (85583172..85906146, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (78580297..78958827, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene general transcription factor 3C polypeptide 6 pseudogene Neighboring gene uncharacterized LOC106997478 Neighboring gene proline rich 15 Neighboring gene uncharacterized LOC114676951 Neighboring gene carboxypeptidase vitellogenic like Neighboring gene uncharacterized LOC106997479

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    beta-chimaerin
    Names
    chimerin (chimaerin) 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261577.1 → NP_001248506.1  beta-chimaerin

      See identical proteins and their annotated locations for NP_001248506.1

      Status: PROVISIONAL

      Source sequence(s)
      JU322076
      UniProtKB/TrEMBL
      A0A1D5R9C0, A0A1D5RC06, H9ETX3
      Related
      ENSMMUP00000057848.2, ENSMMUT00000073602.2
      Conserved Domains (3) summary
      cd10352
      Location:52 → 138
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:275 → 468
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:210 → 270
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      85583172..85906146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015133784.2 → XP_014989270.1  beta-chimaerin isoform X1

      UniProtKB/TrEMBL
      A0A1D5R9C0, F6VWF7
      Related
      ENSMMUP00000035186.3, ENSMMUT00000042187.3
      Conserved Domains (3) summary
      cd10352
      Location:65 → 151
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:288 → 481
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:223 → 283
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

    2. XM_028844820.1 → XP_028700653.1  beta-chimaerin isoform X2

      UniProtKB/TrEMBL
      A0A1D5R9C0
      Related
      ENSMMUP00000056911.2, ENSMMUT00000058935.2
      Conserved Domains (3) summary
      cd10352
      Location:37 → 123
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:260 → 453
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:195 → 255
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

    3. XM_015133785.2 → XP_014989271.1  beta-chimaerin isoform X4

      UniProtKB/TrEMBL
      A0A1D5QMR4, A0A1D5R9C0
      Related
      ENSMMUP00000049339.1, ENSMMUT00000066748.2
      Conserved Domains (3) summary
      cd10352
      Location:53 → 139
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:276 → 469
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:216 → 268
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    4. XM_028844821.1 → XP_028700654.1  beta-chimaerin isoform X5

      UniProtKB/TrEMBL
      H9EMY7
      Conserved Domains (2) summary
      cd04372
      Location:129 → 322
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      pfam00130
      Location:69 → 119
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    5. XM_015133786.2 → XP_014989272.1  beta-chimaerin isoform X3

      UniProtKB/TrEMBL
      H9EMY7
      Conserved Domains (2) summary
      cd04372
      Location:145 → 338
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:85 → 137
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    6. XM_015133787.2 → XP_014989273.1  beta-chimaerin isoform X6

      UniProtKB/TrEMBL
      H9EMY7
      Conserved Domains (2) summary
      cd04372
      Location:99 → 292
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:39 → 91
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.