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    CTLA4 cytotoxic T-lymphocyte associated protein 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 705673, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CTLA4provided by VGNC
    Official Full Name
    cytotoxic T-lymphocyte associated protein 4provided by VGNC
    Primary source
    VGNC:VGNC:71542
    Locus tag
    EGK_04712
    See related
    Ensembl:ENSMMUG00000015903
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    CTLA-4
    Orthologs
    human mouse all
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    Genomic context

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    See CTLA4 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (91268255..91274677)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (85563431..85569571)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene nucleophosmin-like Neighboring gene inducible T cell costimulator Neighboring gene uncharacterized LOC114671528

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CTLA-4(+)PD-1(-) Memory CD4(+) T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques. McGary CS, et al. Immunity, 2017 Oct 17. PMID 29045906, Free PMC Article
    2. Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules. Villinger F, et al. Immunogenetics, 2001 May-Jun. PMID 11491535
    3. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of regulatory T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytotoxic T-lymphocyte protein 4
    Names
    CD152 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044739.1 → NP_001038204.1  cytotoxic T-lymphocyte protein 4 precursor

      See identical proteins and their annotated locations for NP_001038204.1

      Status: PROVISIONAL

      Source sequence(s)
      AF344846
      UniProtKB/TrEMBL
      A0A8J8YNJ8, F7ATH4, G7N8Q3, Q9BDC4
      Related
      ENSMMUP00000020905.4, ENSMMUT00000022346.4
      Conserved Domains (1) summary
      cd05721
      Location:39 → 152
      IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      91268255..91274677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015110723.2 → XP_014966209.1  cytotoxic T-lymphocyte protein 4 isoform X2

      Conserved Domains (2) summary
      cd05721
      Location:39 → 152
      IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
      smart00410
      Location:43 → 132
      IG_like; Immunoglobulin like

    2. XM_015110722.2 → XP_014966208.1  cytotoxic T-lymphocyte protein 4 isoform X1

      UniProtKB/TrEMBL
      F7ATH4
      Conserved Domains (1) summary
      cd05721
      Location:2 → 115
      IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
    Nucleotide Protein
    Heading Accession and Version

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