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    PHLDB2 pleckstrin homology like domain family B member 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 709353, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PHLDB2provided by VGNC
    Official Full Name
    pleckstrin homology like domain family B member 2provided by VGNC
    Primary source
    VGNC:VGNC:75883
    Locus tag
    EGK_11279
    See related
    Ensembl:ENSMMUG00000000694
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PHLDB2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (164202831..164443300, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (32804455..33038522)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene transgelin 3 Neighboring gene abhydrolase domain containing 10, depalmitoylase Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC114676432 Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 2 Neighboring gene uncharacterized LOC106996776 Neighboring gene CD96 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pleckstrin homology-like domain family B member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      164202831..164443300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015129845.2 → XP_014985331.1  pleckstrin homology-like domain family B member 2 isoform X4

      UniProtKB/TrEMBL
      F6YZJ5, G7MK51
      Conserved Domains (4) summary
      cd14673
      Location:1155 → 1259
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1158 → 1254
      PH; PH domain
      cl02488
      Location:639 → 803
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1049 → 1119
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    2. XM_015129847.2 → XP_014985333.1  pleckstrin homology-like domain family B member 2 isoform X5

      UniProtKB/TrEMBL
      F6YZJ5, G7MK51
      Conserved Domains (5) summary
      cd14673
      Location:1103 → 1207
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1106 → 1202
      PH; PH domain
      pfam06008
      Location:580 → 835
      Laminin_I; Laminin Domain I
      cl02488
      Location:694 → 846
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:997 → 1067
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    3. XM_015129844.2 → XP_014985330.1  pleckstrin homology-like domain family B member 2 isoform X3

      UniProtKB/TrEMBL
      F6YZI6, F6YZJ5, G7MK51
      Related
      ENSMMUP00000000935.4, ENSMMUT00000000997.4
      Conserved Domains (5) summary
      cd14673
      Location:1198 → 1302
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1201 → 1297
      PH; PH domain
      pfam06008
      Location:580 → 835
      Laminin_I; Laminin Domain I
      cl02488
      Location:694 → 846
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1092 → 1162
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    4. XM_028844627.1 → XP_028700460.1  pleckstrin homology-like domain family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A5F8AA26
      Conserved Domains (3) summary
      COG1196
      Location:641 → 870
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1285 → 1389
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:1175 → 1270
      DUF5401; Family of unknown function (DUF5401)

    5. XM_015129843.2 → XP_014985329.1  pleckstrin homology-like domain family B member 2 isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZLJ2, A0A5F8AA26
      Related
      ENSMMUP00000065480.1, ENSMMUT00000095502.1
      Conserved Domains (5) summary
      cd14673
      Location:1229 → 1333
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1232 → 1328
      PH; PH domain
      pfam06008
      Location:524 → 779
      Laminin_I; Laminin Domain I
      cl02488
      Location:638 → 790
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1123 → 1193
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    6. XM_015129842.2 → XP_014985328.1  pleckstrin homology-like domain family B member 2 isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZLJ2, A0A5F8AA26
      Conserved Domains (5) summary
      cd14673
      Location:1229 → 1333
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1232 → 1328
      PH; PH domain
      pfam06008
      Location:524 → 779
      Laminin_I; Laminin Domain I
      cl02488
      Location:638 → 790
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1123 → 1193
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    7. XM_028844628.1 → XP_028700461.1  pleckstrin homology-like domain family B member 2 isoform X6

      Conserved Domains (3) summary
      COG1196
      Location:171 → 400
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:815 → 919
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:705 → 800
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein
    Heading Accession and Version

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