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    B2M beta-2-microglobulin [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 712428, updated on 17-Aug-2024

    Summary

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    Official Symbol
    B2Mprovided by VGNC
    Official Full Name
    beta-2-microglobulinprovided by VGNC
    Primary source
    VGNC:VGNC:70203
    Locus tag
    EGK_17447
    See related
    Ensembl:ENSMMUG00000060797
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See B2M in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (21220625..21227670)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (21093941..21100927)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114679390 Neighboring gene eukaryotic translation initiation factor 3 subunit J Neighboring gene SPG11 vesicle trafficking associated, spatacsin Neighboring gene PAT1 homolog 2 Neighboring gene uncharacterized LOC114679391 Neighboring gene tripartite motif containing 69 Neighboring gene U3 small nucleolar ribonucleoprotein protein MPP10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The β2-microglobulin-free heterodimerization of rhesus monkey MHC class I A with its normally spliced variant reduces the ubiquitin-dependent degradation of MHC class I A. Dai ZX, et al. J Immunol, 2012 Mar 1. PMID 22291188
    2. Sequence of beta(2)-microglobulin from rhesus macaque ( Macaca mulatta) includes an allelic variation in the 3'-untranslated region. Su J, et al. Immunogenetics, 2004 Mar. PMID 14963620
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Despite the absence of beta2-microglobulin, histocompatibility class I A spliced- variant proteins reach the cell surface during transfection as glycoproteins that can form disulfide-bonded homodimers.
      Title: The β2-microglobulin-free heterodimerization of rhesus monkey MHC class I A with its normally spliced variant reduces the ubiquitin-dependent degradation of MHC class I A.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class I protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-2-microglobulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047137.1 → NP_001040602.1  beta-2-microglobulin precursor

      See identical proteins and their annotated locations for NP_001040602.1

      Status: PROVISIONAL

      Source sequence(s)
      AY349163
      UniProtKB/Swiss-Prot
      Q6V7J5
      UniProtKB/TrEMBL
      I0FLX5
      Related
      ENSMMUP00000005012.4, ENSMMUT00000005322.4
      Conserved Domains (1) summary
      cd05770
      Location:24 → 116
      IgC_beta2m; Class I major histocompatibility complex (MHC) beta2-microglobulin

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      21220625..21227670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015142098.2 → XP_014997584.1  beta-2-microglobulin isoform X1

      UniProtKB/TrEMBL
      G7MX75, I0FLX5
      Conserved Domains (1) summary
      cd05770
      Location:24 → 115
      IgC_beta2m; Class I major histocompatibility complex (MHC) beta2-microglobulin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6V7J5.1 GenPept UniProtKB/Swiss-Prot:Q6V7J5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.