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    DTX2 deltex E3 ubiquitin ligase 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 719916, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DTX2provided by VGNC
    Official Full Name
    deltex E3 ubiquitin ligase 2provided by VGNC
    Primary source
    VGNC:VGNC:71843
    Locus tag
    EGK_13576
    See related
    Ensembl:ENSMMUG00000017570
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See DTX2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (44710997..44758228, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (40899985..40945955, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene uroplakin 3B like 2 Neighboring gene uroplakin 3B Neighboring gene farnesyl pyrophosphate synthase pseudogene Neighboring gene zona pellucida glycoprotein 3 Neighboring gene scavenger receptor cysteine rich family member with 4 domains

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase DTX2
    Names
    deltex homolog 2
    protein deltex-2
    XP_002803280.1
    XP_014988769.2
    XP_028701465.1
    XP_028701466.1
    XP_028701467.1
    XP_028701468.1
    XP_028701469.1
    XP_028701470.1
    XP_028701471.1
    XP_028701472.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      44710997..44758228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028845639.1 → XP_028701472.1  probable E3 ubiquitin-protein ligase DTX2 isoform X7

      UniProtKB/TrEMBL
      A0A5F7ZAA1
      Related
      ENSMMUP00000062523.1, ENSMMUT00000082837.1
      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:434 → 566
      Deltex_C; Domain found at the C-terminus of deltex-like
      PHA03247
      Location:159 → 329
      PHA03247; large tegument protein UL36; Provisional
      cd16672
      Location:364 → 435
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

    2. XM_028845635.1 → XP_028701468.1  probable E3 ubiquitin-protein ligase DTX2 isoform X5

      Conserved Domains (4) summary
      smart00678
      Location:162 → 246
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:575 → 707
      Deltex_C; Domain found at the C-terminus of deltex-like
      PHA03247
      Location:300 → 470
      PHA03247; large tegument protein UL36; Provisional
      cd16672
      Location:505 → 576
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

    3. XM_015133283.2 → XP_014988769.2  probable E3 ubiquitin-protein ligase DTX2 isoform X2

      Conserved Domains (4) summary
      smart00678
      Location:162 → 246
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:622 → 754
      Deltex_C; Domain found at the C-terminus of deltex-like
      PHA03247
      Location:300 → 551
      PHA03247; large tegument protein UL36; Provisional
      cd16672
      Location:552 → 623
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

    4. XM_002803234.2 → XP_002803280.1  probable E3 ubiquitin-protein ligase DTX2 isoform X6

      See identical proteins and their annotated locations for XP_002803280.1

      UniProtKB/TrEMBL
      A0A8J8YIG4, F6WRL7, G7MNY3
      Related
      ENSMMUP00000023135.2, ENSMMUT00000024717.4
      Conserved Domains (3) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:481 → 613
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:411 → 474
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    5. XM_028845636.1 → XP_028701469.1  probable E3 ubiquitin-protein ligase DTX2 isoform X3

      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:481 → 548
      Deltex_C; Domain found at the C-terminus of deltex-like
      PHA03247
      Location:159 → 395
      PHA03247; large tegument protein UL36; Provisional
      cd16672
      Location:411 → 482
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

    6. XM_028845634.1 → XP_028701467.1  probable E3 ubiquitin-protein ligase DTX2 isoform X4

      Conserved Domains (4) summary
      smart00678
      Location:162 → 246
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:575 → 642
      Deltex_C; Domain found at the C-terminus of deltex-like
      pfam09770
      Location:363 → 493
      PAT1; Topoisomerase II-associated protein PAT1
      cd16672
      Location:505 → 576
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

    7. XM_028845632.1 → XP_028701465.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      Conserved Domains (4) summary
      smart00678
      Location:162 → 246
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:622 → 689
      Deltex_C; Domain found at the C-terminus of deltex-like
      PHA03247
      Location:300 → 536
      PHA03247; large tegument protein UL36; Provisional
      cd16672
      Location:552 → 623
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

    8. XM_028845633.1 → XP_028701466.1  probable E3 ubiquitin-protein ligase DTX2 isoform X3

      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:481 → 548
      Deltex_C; Domain found at the C-terminus of deltex-like
      PHA03247
      Location:159 → 395
      PHA03247; large tegument protein UL36; Provisional
      cd16672
      Location:411 → 482
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

    9. XM_028845638.1 → XP_028701471.1  probable E3 ubiquitin-protein ligase DTX2 isoform X3

      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:481 → 548
      Deltex_C; Domain found at the C-terminus of deltex-like
      PHA03247
      Location:159 → 395
      PHA03247; large tegument protein UL36; Provisional
      cd16672
      Location:411 → 482
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

    10. XM_028845637.1 → XP_028701470.1  probable E3 ubiquitin-protein ligase DTX2 isoform X3

      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:481 → 548
      Deltex_C; Domain found at the C-terminus of deltex-like
      PHA03247
      Location:159 → 395
      PHA03247; large tegument protein UL36; Provisional
      cd16672
      Location:411 → 482
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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