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    ECT2 epithelial cell transforming 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694056, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ECT2provided by VGNC
    Official Full Name
    epithelial cell transforming 2provided by VGNC
    Primary source
    VGNC:VGNC:72152
    See related
    Ensembl:ENSMMUG00000017014
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ECT2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (77701828..77773721)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (120952378..121024132, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene high affinity copper uptake protein 1 pseudogene Neighboring gene neutral cholesterol ester hydrolase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA72 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)-like Neighboring gene spermatogenesis associated 16 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytokinesis, actomyosin contractile ring assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein ECT2
    Names
    epithelial cell transforming sequence 2 oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      77701828..77773721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001083830.4 → XP_001083830.2  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A5F8A9K1
      Conserved Domains (4) summary
      smart00325
      Location:425 → 609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600 → 773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:239 → 318
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:145 → 220
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    2. XM_015131616.2 → XP_014987102.2  protein ECT2 isoform X4

      UniProtKB/TrEMBL
      A0A5F8A9K1, F6PMC7
      Related
      ENSMMUP00000073641.1, ENSMMUT00000094576.1
      Conserved Domains (4) summary
      smart00325
      Location:425 → 609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600 → 773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:239 → 318
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:145 → 220
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    3. XM_015131612.2 → XP_014987098.2  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A5F8A9K1, F6WHV5
      Conserved Domains (4) summary
      smart00325
      Location:456 → 640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:270 → 349
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:176 → 251
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    4. XM_015131615.2 → XP_014987101.2  protein ECT2 isoform X3

      UniProtKB/TrEMBL
      A0A5F8A9K1
      Conserved Domains (4) summary
      smart00325
      Location:456 → 640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:270 → 349
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:176 → 251
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    5. XM_015131611.2 → XP_014987097.2  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A5F8A9K1, F6WHV5
      Related
      ENSMMUP00000038715.3, ENSMMUT00000045672.3
      Conserved Domains (4) summary
      smart00325
      Location:456 → 640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:270 → 349
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:176 → 251
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    6. XM_028843859.1 → XP_028699692.1  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A5F8A9K1
      Conserved Domains (4) summary
      smart00325
      Location:425 → 609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600 → 773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:239 → 318
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:145 → 220
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    7. XM_015131613.2 → XP_014987099.2  protein ECT2 isoform X3

      UniProtKB/TrEMBL
      A0A5F8A9K1
      Conserved Domains (4) summary
      smart00325
      Location:456 → 640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:270 → 349
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:176 → 251
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    8. XM_028843860.1 → XP_028699693.1  protein ECT2 isoform X4

      UniProtKB/TrEMBL
      A0A5F8A9K1, F6PMC7
      Related
      ENSMMUP00000022390.4, ENSMMUT00000023920.4
      Conserved Domains (4) summary
      smart00325
      Location:425 → 609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600 → 773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:239 → 318
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:145 → 220
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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