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    CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 678692, updated on 9-Nov-2023

    Summary

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    Gene symbol
    CYP3A5
    Gene description
    cytochrome P450, family 3, subfamily A, polypeptide 5
    See related
    Ensembl:ENSMMUG00000022730
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    CYP3A66
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    Genomic context

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    See CYP3A5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (41759896..41805887, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (125092064..125119253, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 655 Neighboring gene transmembrane protein 225B Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene cytochrome P450 family 3 subfamily A member 7 Neighboring gene uncharacterized LOC114676874 Neighboring gene cytochrome P450 3A7-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques. Uno Y, et al. Drug Metab Dispos, 2010 Feb. PMID 19910514
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study of genetic variants of CYP3A5 in cynomolgus macaques from China
      Title: Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables testosterone 6-beta-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oxidative demethylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 3A5
    Names
    cytochrome P450 CYP3A66
    NP_001035309.1
    XP_028700598.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040219.1 → NP_001035309.1  cytochrome P450 3A5

      See identical proteins and their annotated locations for NP_001035309.1

      Status: PROVISIONAL

      Source sequence(s)
      AY635466
      UniProtKB/TrEMBL
      F7A3P6, F7DPC7, Q6GUQ3
      Related
      ENSMMUP00000035478.3, ENSMMUT00000042472.3
      Conserved Domains (1) summary
      pfam00067
      Location:39 → 493
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      41759896..41805887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028844765.1 → XP_028700598.1  cytochrome P450 3A5 isoform X1

      UniProtKB/TrEMBL
      F7DPC7
      Conserved Domains (1) summary
      pfam00067
      Location:39 → 493
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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