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    PNKP polynucleotide kinase 3'-phosphatase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 719084, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PNKPprovided by VGNC
    Official Full Name
    polynucleotide kinase 3'-phosphataseprovided by VGNC
    Primary source
    VGNC:VGNC:76196
    See related
    Ensembl:ENSMMUG00000011622
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PNKP in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (49841389..49847817, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (45286445..45292920, complement)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene fuzzy planar cell polarity protein Neighboring gene mediator complex subunit 25 Neighboring gene uncharacterized LOC114673979 Neighboring gene PTOV1 extended AT-hook containing adaptor protein Neighboring gene AKT1 substrate 1 Neighboring gene TBC1 domain family member 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PNKP knockdown by RNA interference inhibits herpes simplex virus-1 replication in astrocytes. Yue L, et al. Virol Sin, 2013 Dec. PMID 24213989, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study preliminarily confirms that PNKP affects viral proliferation by affecting herpes simplex virus-1 genome cyclization.
      Title: PNKP knockdown by RNA interference inhibits herpes simplex virus-1 replication in astrocytes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables polynucleotide 3'-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional polynucleotide phosphatase/kinase
    XP_014980108.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      49841389..49847817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015124622.2 → XP_014980108.2  bifunctional polynucleotide phosphatase/kinase

      UniProtKB/TrEMBL
      F6PK17, H9EWT0
      Related
      ENSMMUP00000015256.3, ENSMMUT00000016284.4
      Conserved Domains (1) summary
      TIGR01663
      Location:2 → 521
      PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
    Nucleotide Protein
    Heading Accession and Version

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