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    CRBN cereblon [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 704436, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CRBNprovided by VGNC
    Official Full Name
    cereblonprovided by VGNC
    Primary source
    VGNC:VGNC:71607
    See related
    Ensembl:ENSMMUG00000017986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CRBN in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (134481753..134512704, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (63389059..63418364)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene interleukin 5 receptor subunit alpha Neighboring gene uncharacterized LOC106996851 Neighboring gene tRNA nucleotidyl transferase 1 Neighboring gene uncharacterized LOC114676152 Neighboring gene uncharacterized LOC106996850

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human. Magness CL, et al. Genome Biol, 2005. PMID 15998449, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4A-RING E3 ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein cereblon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195647.1 → NP_001182576.1  protein cereblon

      See identical proteins and their annotated locations for NP_001182576.1

      Status: VALIDATED

      Source sequence(s)
      CO579336, DQ147997, EG702761, QNVO02000283
      UniProtKB/TrEMBL
      A0A5F7ZMZ6, F7DSP3, H9FVB2
      Related
      ENSMMUP00000065991.1, ENSMMUT00000091357.1
      Conserved Domains (2) summary
      cd15777
      Location:321 → 422
      CRBN_C_like; Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains
      pfam02190
      Location:80 → 317
      LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      134481753..134512704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028843227.1 → XP_028699060.1  protein cereblon isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZMZ6, A0A5K1VSA6
      Related
      ENSMMUP00000023638.4, ENSMMUT00000025267.4
      Conserved Domains (2) summary
      cd15777
      Location:320 → 421
      CRBN_C_like; Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains
      pfam02190
      Location:79 → 316
      LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    Nucleotide Protein
    Heading Accession and Version

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