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    ADAM18 ADAM metallopeptidase domain 18 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701958, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ADAM18provided by VGNC
    Official Full Name
    ADAM metallopeptidase domain 18provided by VGNC
    Primary source
    VGNC:VGNC:83975
    See related
    Ensembl:ENSMMUG00000022134
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
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    Genomic context

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    See ADAM18 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (40132208..40292290)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (40040060..40232682)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene disintegrin and metalloproteinase domain-containing protein 5 Neighboring gene A disintegrin and metallopeptidase domain 3-like Neighboring gene serine/arginine-rich splicing factor 3 Neighboring gene ADAM metallopeptidase domain 2 Neighboring gene indoleamine 2,3-dioxygenase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      40132208..40292290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028852610.1 → XP_028708443.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X7

      UniProtKB/TrEMBL
      F7H3F8
      Conserved Domains (4) summary
      smart00050
      Location:303 → 369
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:371 → 510
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:184 → 303
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:47 → 141
      Pep_M12B_propep; Reprolysin family propeptide

    2. XM_028852608.1 → XP_028708441.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X5

      UniProtKB/TrEMBL
      F7H3F8
      Conserved Domains (4) summary
      smart00050
      Location:399 → 476
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:478 → 617
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:184 → 380
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:47 → 141
      Pep_M12B_propep; Reprolysin family propeptide

    3. XM_015145218.2 → XP_015000704.2  disintegrin and metalloproteinase domain-containing protein 18 isoform X2

      UniProtKB/TrEMBL
      F7H3F8
      Conserved Domains (4) summary
      smart00050
      Location:375 → 452
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:454 → 593
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:184 → 356
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:47 → 141
      Pep_M12B_propep; Reprolysin family propeptide

    4. XM_015145216.2 → XP_015000702.2  disintegrin and metalloproteinase domain-containing protein 18 isoform X1

      UniProtKB/TrEMBL
      F7H3F8
      Related
      ENSMMUP00000029143.4, ENSMMUT00000031137.4
      Conserved Domains (4) summary
      smart00050
      Location:399 → 476
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:478 → 617
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:184 → 380
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:47 → 141
      Pep_M12B_propep; Reprolysin family propeptide

    5. XM_028852606.1 → XP_028708439.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X4

      UniProtKB/TrEMBL
      F7H3F8
      Conserved Domains (4) summary
      smart00050
      Location:355 → 432
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:434 → 573
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:140 → 336
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:3 → 97
      Pep_M12B_propep; Reprolysin family propeptide

    6. XM_015145219.2 → XP_015000705.2  disintegrin and metalloproteinase domain-containing protein 18 isoform X3

      UniProtKB/TrEMBL
      F7H3F8
      Conserved Domains (4) summary
      smart00050
      Location:363 → 440
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:442 → 581
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:148 → 344
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:11 → 105
      Pep_M12B_propep; Reprolysin family propeptide

    7. XM_028852607.1 → XP_028708440.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X4

      UniProtKB/TrEMBL
      F7H3F8
      Conserved Domains (4) summary
      smart00050
      Location:355 → 432
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:434 → 573
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:140 → 336
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:3 → 97
      Pep_M12B_propep; Reprolysin family propeptide

    8. XM_015145220.2 → XP_015000706.2  disintegrin and metalloproteinase domain-containing protein 18 isoform X3

      UniProtKB/TrEMBL
      F7H3F8
      Conserved Domains (4) summary
      smart00050
      Location:363 → 440
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:442 → 581
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:148 → 344
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:11 → 105
      Pep_M12B_propep; Reprolysin family propeptide

    9. XM_028852609.1 → XP_028708442.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X6

      UniProtKB/TrEMBL
      F7H3F8
      Conserved Domains (4) summary
      smart00050
      Location:310 → 387
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:389 → 528
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:95 → 291
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:2 → 52
      Pep_M12B_propep; Reprolysin family propeptide
    Nucleotide Protein
    Heading Accession and Version

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