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    DNMT3A DNA methyltransferase 3 alpha [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694822, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DNMT3Aprovided by VGNC
    Official Full Name
    DNA methyltransferase 3 alphaprovided by VGNC
    Primary source
    VGNC:VGNC:71959
    See related
    Ensembl:ENSMMUG00000013565
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See DNMT3A in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (83632251..83747543)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 13 NC_027905.1 (25477990..25589676, complement)

    Chromosome 13 - NC_041766.1Genomic Context describing neighboring genes Neighboring gene ASXL transcriptional regulator 2 Neighboring gene U2 spliceosomal RNA Neighboring gene dystrobrevin beta Neighboring gene uncharacterized LOC114671755 Neighboring gene non-histone chromosomal protein HMG-14 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA (cytosine-5-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA (cytosine-5)-methyltransferase 3A
    XP_014967323.1
    XP_014967324.1
    XP_014967325.1
    XP_014967326.1
    XP_014967327.2
    XP_028687753.1
    XP_028687754.1
    XP_028687755.1
    XP_028687756.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041766.1 Reference Mmul_10 Primary Assembly

      Range
      83632251..83747543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028831922.1 → XP_028687755.1  DNA (cytosine-5)-methyltransferase 3A isoform X3

      UniProtKB/TrEMBL
      H9F9A6
      Conserved Domains (3) summary
      cd05835
      Location:191 → 277
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:533 → 696
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:388 → 515
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

    2. XM_015111837.2 → XP_014967323.1  DNA (cytosine-5)-methyltransferase 3A isoform X1

      UniProtKB/TrEMBL
      F6QRP0, G7N9K1
      Conserved Domains (5) summary
      cd05835
      Location:287 → 373
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      PTZ00449
      Location:1 → 127
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:2 → 290
      PHA03307; transcriptional regulator ICP4; Provisional
      cd11729
      Location:484 → 611
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
      cl30459
      Location:629 → 792
      Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

    3. XM_015111841.2 → XP_014967327.2  DNA (cytosine-5)-methyltransferase 3A isoform X3

      UniProtKB/TrEMBL
      H9F9A6
      Conserved Domains (3) summary
      cd05835
      Location:191 → 277
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:533 → 696
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:388 → 515
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

    4. XM_028831920.1 → XP_028687753.1  DNA (cytosine-5)-methyltransferase 3A isoform X1

      UniProtKB/TrEMBL
      F6QRP0, G7N9K1
      Related
      ENSMMUP00000025595.4, ENSMMUT00000027363.4
      Conserved Domains (5) summary
      cd05835
      Location:287 → 373
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      PTZ00449
      Location:1 → 127
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:2 → 290
      PHA03307; transcriptional regulator ICP4; Provisional
      cd11729
      Location:484 → 611
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
      cl30459
      Location:629 → 792
      Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

    5. XM_015111838.2 → XP_014967324.1  DNA (cytosine-5)-methyltransferase 3A isoform X1

      UniProtKB/TrEMBL
      F6QRP0, G7N9K1
      Conserved Domains (5) summary
      cd05835
      Location:287 → 373
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      PTZ00449
      Location:1 → 127
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:2 → 290
      PHA03307; transcriptional regulator ICP4; Provisional
      cd11729
      Location:484 → 611
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
      cl30459
      Location:629 → 792
      Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

    6. XM_028831921.1 → XP_028687754.1  DNA (cytosine-5)-methyltransferase 3A isoform X2

      UniProtKB/TrEMBL
      H9F9A6
      Conserved Domains (3) summary
      cd05835
      Location:213 → 299
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:555 → 718
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:410 → 537
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

    7. XM_015111840.2 → XP_014967326.1  DNA (cytosine-5)-methyltransferase 3A isoform X6

      UniProtKB/TrEMBL
      H9F9A6
      Conserved Domains (3) summary
      cd05835
      Location:101 → 187
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:443 → 606
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:298 → 425
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

    8. XM_015111839.2 → XP_014967325.1  DNA (cytosine-5)-methyltransferase 3A isoform X5

      UniProtKB/TrEMBL
      H9F9A6
      Conserved Domains (3) summary
      cd05835
      Location:114 → 200
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:456 → 619
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:311 → 438
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

    9. XM_028831923.1 → XP_028687756.1  DNA (cytosine-5)-methyltransferase 3A isoform X4

      UniProtKB/TrEMBL
      H9F9A6
      Conserved Domains (4) summary
      cd05835
      Location:138 → 224
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:480 → 643
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      PRK07003
      Location:2 → 130
      PRK07003; DNA polymerase III subunit gamma/tau
      cd11729
      Location:335 → 462
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

    RNA

    1. XR_003721836.1 RNA Sequence

    2. XR_003721835.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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