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    EP300 E1A binding protein p300 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 706258, updated on 17-Aug-2024

    Summary

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    Official Symbol
    EP300provided by VGNC
    Official Full Name
    E1A binding protein p300provided by VGNC
    Primary source
    VGNC:VGNC:72228
    Locus tag
    EGK_03079
    See related
    Ensembl:ENSMMUG00000000893
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See EP300 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (10337194..10427870, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (83142620..83233184)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114670352 Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene uncharacterized LOC107000674 Neighboring gene U6 spliceosomal RNA Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene acyl-CoA-binding protein Neighboring gene actin, cytoplasmic 1-like Neighboring gene ring-box 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone acetyltransferase p300
    NP_001253415.1
    XP_015005880.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266486.1 → NP_001253415.1  histone acetyltransferase p300

      See identical proteins and their annotated locations for NP_001253415.1

      Status: PROVISIONAL

      Source sequence(s)
      JU333331
      UniProtKB/TrEMBL
      A0A5F8AFL2, A0A8J8YH29, F6T7D0, G7N3Y2
      Related
      ENSMMUP00000076664.1, ENSMMUT00000080799.1
      Conserved Domains (11) summary
      cd05495
      Location:1051 → 1158
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:1729 → 1807
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:1668 → 1708
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      pfam08430
      Location:124 → 258
      Forkhead_N; Forkhead N-terminal region
      pfam09606
      Location:1937 → 2412
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15802
      Location:1170 → 1242
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15646
      Location:1243 → 1277
      PHD_p300; PHD finger found in histone acetyltransferase p300
      pfam02135
      Location:347 → 414
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:566 → 646
      KIX; KIX domain
      pfam08214
      Location:1306 → 1612
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:2005 → 2095
      Creb_binding; Creb binding

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      10337194..10427870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015150394.2 → XP_015005880.1  histone acetyltransferase p300 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZS56, F6T7D0
      Related
      ENSMMUP00000068451.1, ENSMMUT00000089464.1
      Conserved Domains (11) summary
      cd05495
      Location:969 → 1076
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:1647 → 1725
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:1586 → 1626
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      pfam08430
      Location:124 → 258
      Forkhead_N; Forkhead N-terminal region
      pfam09606
      Location:1855 → 2330
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15802
      Location:1088 → 1160
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15646
      Location:1161 → 1195
      PHD_p300; PHD finger found in histone acetyltransferase p300
      pfam02135
      Location:347 → 414
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:484 → 564
      KIX; KIX domain
      pfam08214
      Location:1224 → 1530
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:1923 → 2013
      Creb_binding; Creb binding
    Nucleotide Protein
    Heading Accession and Version

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