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    RAPGEF4 Rap guanine nucleotide exchange factor 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 698148, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RAPGEF4provided by VGNC
    Official Full Name
    Rap guanine nucleotide exchange factor 4provided by VGNC
    Primary source
    VGNC:VGNC:76490
    See related
    Ensembl:ENSMMUG00000020792
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See RAPGEF4 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (59830631..60140600)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (59749432..60058894)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100430028 Neighboring gene pyruvate dehydrogenase kinase 1 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC100428990 Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC114671359 Neighboring gene mitogen-activated protein kinase kinase kinase 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rap guanine nucleotide exchange factor 4
    Names
    Rap guanine nucleotide exchange factor (GEF) 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      59830631..60140600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028830842.1 → XP_028686675.1  rap guanine nucleotide exchange factor 4 isoform X3

      UniProtKB/TrEMBL
      G7N8B6
      Conserved Domains (4) summary
      smart00147
      Location:768 → 969
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43 → 158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:206 → 334
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:499 → 605
      RasGEF_N; RasGEF N-terminal motif

    2. XM_015110377.2 → XP_014965863.1  rap guanine nucleotide exchange factor 4 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QP16, G7N8B6
      Related
      ENSMMUP00000049793.2, ENSMMUT00000069257.2
      Conserved Domains (4) summary
      smart00147
      Location:768 → 1009
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43 → 158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:206 → 334
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:499 → 605
      RasGEF_N; RasGEF N-terminal motif

    3. XM_015110378.2 → XP_014965864.1  rap guanine nucleotide exchange factor 4 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QAF1
      Related
      ENSMMUP00000045019.2, ENSMMUT00000074622.2
      Conserved Domains (4) summary
      smart00147
      Location:750 → 991
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43 → 158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:188 → 316
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:481 → 587
      RasGEF_N; RasGEF N-terminal motif

    4. XM_015110379.2 → XP_014965865.1  rap guanine nucleotide exchange factor 4 isoform X4

      UniProtKB/TrEMBL
      G7N8B6
      Conserved Domains (4) summary
      smart00147
      Location:624 → 865
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:212 → 323
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:62 → 190
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:355 → 461
      RasGEF_N; RasGEF N-terminal motif

    5. XM_015110381.2 → XP_014965867.1  rap guanine nucleotide exchange factor 4 isoform X6

      UniProtKB/TrEMBL
      G7N8B6
      Conserved Domains (4) summary
      smart00147
      Location:597 → 838
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:185 → 296
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:35 → 163
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:328 → 434
      RasGEF_N; RasGEF N-terminal motif

    6. XM_015110380.2 → XP_014965866.1  rap guanine nucleotide exchange factor 4 isoform X5

      UniProtKB/TrEMBL
      G7N8B6
      Conserved Domains (4) summary
      smart00147
      Location:615 → 856
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:203 → 314
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:53 → 181
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:346 → 452
      RasGEF_N; RasGEF N-terminal motif

    7. XM_015110382.2 → XP_014965868.1  rap guanine nucleotide exchange factor 4 isoform X7

      UniProtKB/TrEMBL
      G7N8B6
      Conserved Domains (4) summary
      smart00147
      Location:595 → 836
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:183 → 294
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:33 → 161
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:326 → 432
      RasGEF_N; RasGEF N-terminal motif
    Nucleotide Protein
    Heading Accession and Version

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