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    OXTR oxytocin receptor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 702048, updated on 17-Aug-2024

    Summary

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    Official Symbol
    OXTRprovided by VGNC
    Official Full Name
    oxytocin receptorprovided by VGNC
    Primary source
    VGNC:VGNC:75731
    See related
    Ensembl:ENSMMUG00000009703
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See OXTR in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (140082970..140103796, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (57649844..57664987)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene ssu-2 homolog Neighboring gene caveolin 3 Neighboring gene small nucleolar RNA SNORA43 Neighboring gene RAD18 E3 ubiquitin protein ligase Neighboring gene SLIT-ROBO Rho GTPase activating protein 3 Neighboring gene uncharacterized LOC114676388

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of the rhesus monkey oxytocin receptor. Salvatore CA, et al. J Recept Signal Transduct Res, 1998 Jan. PMID 9493565
    2. Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques. De Leon D, et al. Horm Behav, 2020 Nov. PMID 32979349, Free PMC Article
    3. Oxytocin receptors in the primate ovary: molecular identity and link to apoptosis in human granulosa cells. Saller S, et al. Hum Reprod, 2010 Apr. PMID 20097922, Free PMC Article
    4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques.
      Title: Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques.
    2. Immunoreactive OTR was detected in primordial and growing primary follicles in the infantile ovary and in follicles at all stages of development in the adult ovary.
      Title: Oxytocin receptors in the primate ovary: molecular identity and link to apoptosis in human granulosa cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables oxytocin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables vasopressin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in maternal process involved in parturition IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of systemic arterial blood pressure by vasopressin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    oxytocin receptor
    Names
    OT-R

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044732.1 → NP_001038197.1  oxytocin receptor

      See identical proteins and their annotated locations for NP_001038197.1

      Status: PROVISIONAL

      Source sequence(s)
      U82440
      UniProtKB/Swiss-Prot
      P56494
      UniProtKB/TrEMBL
      G7MKT1
      Related
      ENSMMUP00000012694.1, ENSMMUT00000013548.3
      Conserved Domains (1) summary
      cd15387
      Location:40 → 340
      7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      140082970..140103796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028843186.1 → XP_028699019.1  oxytocin receptor isoform X1

      UniProtKB/Swiss-Prot
      P56494
      UniProtKB/TrEMBL
      G7MKT1
      Related
      ENSMMUP00000064448.1, ENSMMUT00000083266.1
      Conserved Domains (1) summary
      cd15387
      Location:40 → 340
      7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56494.1 GenPept UniProtKB/Swiss-Prot:P56494

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.