Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc5a2provided by MGI
Official Full Name: solute carrier family 5 (sodium/glucose cotransporter), member 2provided by MGI
Primary source: MGI:MGI:2181411
See related: Ensembl:ENSMUSG00000030781 AllianceGenome:MGI:2181411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sglt2
Summary: Predicted to enable D-glucose:sodium symporter activity and alpha-glucoside transmembrane transporter activity. Involved in renal D-glucose absorption. Located in apical plasma membrane. Is expressed in urinary system. Human ortholog(s) of this gene implicated in familial renal glucosuria and renal glycosuria. Orthologous to human SLC5A2 (solute carrier family 5 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 372.3) and adrenal adult (RPKM 11.1) See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 70.08 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127864855..127871602)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (128265683..128272430)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SGLT2 knockdown restores the Th17/Treg balance and suppresses diabetic nephropathy in db/db mice by regulating SGK1 via Na.
Title: SGLT2 knockdown restores the Th17/Treg balance and suppresses diabetic nephropathy in db/db mice by regulating SGK1 via Na().
Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis.
Title: Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis.
Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption.
Title: Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption.
Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2.
Title: Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2.
Hedgehog interacting protein activates sodium-glucose cotransporter 2 expression and promotes renal tubular epithelial cell senescence in a mouse model of type 1 diabetes.
Title: Hedgehog interacting protein activates sodium-glucose cotransporter 2 expression and promotes renal tubular epithelial cell senescence in a mouse model of type 1 diabetes.
Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney.
Title: Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney.
Col4a3(-/-) Mice on Balb/C Background Have Less Severe Cardiorespiratory Phenotype and SGLT2 Over-Expression Compared to 129x1/SvJ and C57Bl/6 Backgrounds.
Title: Col4a3(-/-) Mice on Balb/C Background Have Less Severe Cardiorespiratory Phenotype and SGLT2 Over-Expression Compared to 129x1/SvJ and C57Bl/6 Backgrounds.
circ_000166/miR-296 Aggravates the Process of Diabetic Renal Fibrosis by Regulating the SGLT2 Signaling Pathway in Renal Tubular Epithelial Cells.
Title: circ_000166/miR-296 Aggravates the Process of Diabetic Renal Fibrosis by Regulating the SGLT2 Signaling Pathway in Renal Tubular Epithelial Cells.
SGLT2 inhibitor counteracts NLRP3 inflammasome via tubular metabolite itaconate in fibrosis kidney.
Title: SGLT2 inhibitor counteracts NLRP3 inflammasome via tubular metabolite itaconate in fibrosis kidney.
Impact of an SGLT2-loss of function mutation on renal architecture, histology, and glucose homeostasis.
Title: Impact of an SGLT2-loss of function mutation on renal architecture, histology, and glucose homeostasis.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (6) 1 citation
Spontaneous (1) 1 citation
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables D-glucose:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables D-glucose:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables alpha-glucoside transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables alpha-glucoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in D-glucose import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in D-glucose import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in alpha-glucoside transport	IEA Inferred from Electronic Annotation more info
involved_in alpha-glucoside transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in renal D-glucose absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal potassium excretion	ISO Inferred from Sequence Orthology more info
involved_in sodium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/glucose cotransporter 2

Names: Na(+)/glucose cotransporter 2; low affinity sodium-dependent glucose cotransporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133254.5 → NP_573517.1 sodium/glucose cotransporter 2

See identical proteins and their annotated locations for NP_573517.1

Status: VALIDATED

Source sequence(s)

AC124566

Consensus CDS

CCDS21894.1

UniProtKB/Swiss-Prot

Q923I7

Related

ENSMUSP00000112597.2, ENSMUST00000118169.8

Conserved Domains (1) summary

cl00456
Location:22 → 670

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain