Elac1 elaC ribonuclease Z 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elac1provided by MGI
Official Full Name: elaC ribonuclease Z 1provided by MGI
Primary source: MGI:MGI:1890495
See related: Ensembl:ENSMUSG00000036941 AllianceGenome:MGI:1890495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610018O07Rik; 8430417G19Rik
Summary: Predicted to enable 3'-tRNA processing endoribonuclease activity and tRNA-specific ribonuclease activity. Predicted to be involved in rescue of stalled ribosome and tRNA 3'-end processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ELAC1 (elaC ribonuclease Z 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 4.6), frontal lobe adult (RPKM 3.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E2; 18 49.83 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (73868109..73887589, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (73735038..73754519, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transposon induced (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-tRNA processing endoribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-tRNA processing endoribonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tRNA-specific ribonuclease activity	ISO Inferred from Sequence Orthology more info
enables tRNA-specific ribonuclease activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in rescue of stalled ribosome	IEA Inferred from Electronic Annotation more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in tRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in tRNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc phosphodiesterase ELAC protein 1

Names: RNase Z 1; elaC homolog 1; elaC homolog protein 1; ribonuclease Z 1; tRNA 3 endonuclease 1; tRNase Z 1

NP_444485.2

EC 3.1.26.11

XP_030106136.1

EC 3.1.26.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053255.3 → NP_444485.2 zinc phosphodiesterase ELAC protein 1

See identical proteins and their annotated locations for NP_444485.2

Status: VALIDATED

Source sequence(s)

AC132418, AF308697, AK018424, BY286576, CV556353

Consensus CDS

CCDS37855.1

UniProtKB/Swiss-Prot

Q8VEB6, Q9CXB1, Q9ERF4

Related

ENSMUSP00000041793.3, ENSMUST00000041138.3

Conserved Domains (2) summary

COG1234
Location:3 → 359

ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]

TIGR02651
Location:4 → 358

RNase_Z; ribonuclease Z

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

73868109..73887589 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250276.2 → XP_030106136.1 zinc phosphodiesterase ELAC protein 1 isoform X1

Conserved Domains (1) summary

cd07717
Location:5 → 195

RNaseZ_ZiPD-like_MBL-fold; Ribonuclease Z, E. coli 3' tRNA-processing endonuclease ZiPD and related proteins; MBL-fold metallo-hydrolase domain