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    Dpp6 dipeptidylpeptidase 6 [ Mus musculus (house mouse) ]

    Gene ID: 13483, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dpp6provided by MGI
    Official Full Name
    dipeptidylpeptidase 6provided by MGI
    Primary source
    MGI:MGI:94921
    See related
    Ensembl:ENSMUSG00000061576 AllianceGenome:MGI:94921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rw; Dpp-6; Peplb; D5Buc3; D5Buc4; D5Buc5; DPP VI; Gm1377; In(5)6H-p; B930011P16Rik
    Summary
    Enables potassium channel regulator activity. Involved in protein localization to plasma membrane; regulation of postsynaptic membrane potential; and regulation of potassium ion transmembrane transport. Acts upstream of or within neuronal action potential and positive regulation of potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. Is active in synapse. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; intervertebral disc; and nose. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 32.7), frontal lobe adult (RPKM 23.3) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Dpp6 in Genome Data Viewer
    Location:
    5 B1; 5 12.92 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (27022355..27932498)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (26817357..27727500)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930584F24 gene Neighboring gene STARR-seq mESC enhancer starr_12679 Neighboring gene predicted gene, 34536 Neighboring gene STARR-seq mESC enhancer starr_12680 Neighboring gene STARR-seq mESC enhancer starr_12681 Neighboring gene STARR-seq mESC enhancer starr_12682 Neighboring gene STARR-seq mESC enhancer starr_12683 Neighboring gene STARR-seq mESC enhancer starr_12685 Neighboring gene STARR-seq mESC enhancer starr_12686 Neighboring gene STARR-seq mESC enhancer starr_12689 Neighboring gene Dpp6 Hedgehog-responsive enhancer Neighboring gene nucleoside diphosphate kinase B pseudogene Neighboring gene STARR-seq mESC enhancer starr_12691 Neighboring gene STARR-seq mESC enhancer starr_12692 Neighboring gene STARR-seq mESC enhancer starr_12693 Neighboring gene STARR-seq mESC enhancer starr_12699 Neighboring gene STARR-seq mESC enhancer starr_12703 Neighboring gene STARR-seq mESC enhancer starr_12704 Neighboring gene STARR-seq mESC enhancer starr_12705 Neighboring gene spermatogenesis associated glutamate (E)-rich protein 4B Neighboring gene STARR-seq mESC enhancer starr_12706 Neighboring gene predicted gene 16058 Neighboring gene STARR-positive B cell enhancer ABC_E3565 Neighboring gene STARR-seq mESC enhancer starr_12707 Neighboring gene STARR-seq mESC enhancer starr_12709 Neighboring gene PAX interacting (with transcription-activation domain) protein 1 Neighboring gene predicted gene, 20239

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Clone Names

    • MGC113720

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables dipeptidyl-peptidase activity  
    enables potassium channel regulator activity  
    enables potassium channel regulator activity PubMed 
    enables potassium channel regulator activity  
    enables protein binding PubMed 
    enables serine-type peptidase activity  
    Process Evidence Code Pubs
    acts_upstream_of establishment of localization in cell PubMed 
    acts_upstream_of_or_within neuronal action potential PubMed 
    acts_upstream_of_or_within positive regulation of potassium ion transmembrane transport PubMed 
    involved_in positive regulation of potassium ion transport  
    involved_in positive regulation of protein localization to plasma membrane  
    acts_upstream_of potassium ion transmembrane transport PubMed 
    involved_in protein localization to plasma membrane PubMed 
    involved_in proteolysis  
    acts_upstream_of_or_within regulation of membrane potential PubMed 
    involved_in regulation of postsynaptic membrane potential PubMed 
    involved_in regulation of postsynaptic membrane potential PubMed 
    involved_in regulation of postsynaptic membrane potential PubMed 
    involved_in regulation of potassium ion transmembrane transport  
    involved_in regulation of potassium ion transmembrane transport PubMed 
    acts_upstream_of_or_within regulation of potassium ion transmembrane transport PubMed 
    involved_in regulation of potassium ion transmembrane transport  
    acts_upstream_of_or_within regulation of potassium ion transport PubMed 
    Component Evidence Code Pubs
    located_in cell surface  
    located_in membrane PubMed 
    located_in membrane  
    located_in neuronal cell body  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    is_active_in synapse PubMed 
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex PubMed 
    part_of voltage-gated potassium channel complex  

    General protein information

    Preferred Names
    A-type potassium channel modulatory protein DPP6
    Names
    DPPX
    dipeptidyl aminopeptidase-like protein 6
    dipeptidyl aminopeptidase-related protein
    dipeptidyl peptidase IV-like protein
    dipeptidyl peptidase VI
    dipeptidylpeptidase VI
    inversion, Chr 5, Harwell 6, proximal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136060.2NP_001129532.1  A-type potassium channel modulatory protein DPP6 isoform 1

      See identical proteins and their annotated locations for NP_001129532.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has an alternate upstream 5' exon, as compared to variant 3. The resulting isoform (1) is shorter and has a different N-terminus, as compared to isoform 3.
      Source sequence(s)
      AK031903, BC048383, BY127642
      Consensus CDS
      CCDS51447.1
      UniProtKB/TrEMBL
      Q3TY19, Q80VM5
      Related
      ENSMUSP00000099012.4, ENSMUST00000101471.4
      Conserved Domains (2) summary
      pfam00930
      Location:133499
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:583785
      Abhydrolase; alpha/beta hydrolases
    2. NM_001198886.1NP_001185815.1  A-type potassium channel modulatory protein DPP6 isoform 4

      See identical proteins and their annotated locations for NP_001185815.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate upstream 5' exon, as compared to variant 3. The resulting isoform (4) is shorter and has a different N-terminus, as compared to isoform 3.
      Source sequence(s)
      AK031903, BC085154
      Consensus CDS
      CCDS57332.1
      UniProtKB/TrEMBL
      Q3TY19, Q5U4C2
      Related
      ENSMUSP00000113849.2, ENSMUST00000120555.8
      Conserved Domains (2) summary
      pfam00930
      Location:131497
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:581783
      Abhydrolase; alpha/beta hydrolases
    3. NM_010075.2NP_034205.1  A-type potassium channel modulatory protein DPP6 isoform 2

      See identical proteins and their annotated locations for NP_034205.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate upstream 5' exon, as compared to variant 3. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 3.
      Source sequence(s)
      AF092507, AK031903
      Consensus CDS
      CCDS19139.1
      UniProtKB/Swiss-Prot
      Q9QWW2, Q9Z218, Q9Z219
      UniProtKB/TrEMBL
      Q3TY19
      Related
      ENSMUSP00000071435.7, ENSMUST00000071500.13
      Conserved Domains (2) summary
      pfam00930
      Location:134500
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:584786
      Abhydrolase; alpha/beta hydrolases
    4. NM_207282.3NP_997165.2  A-type potassium channel modulatory protein DPP6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AF092507, AK031903, AK158964, BY280444
      Consensus CDS
      CCDS51446.1
      UniProtKB/TrEMBL
      E9PWX1, Q3TY19
      Related
      ENSMUSP00000113441.2, ENSMUST00000122171.8
      Conserved Domains (2) summary
      pfam00930
      Location:189555
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:639841
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      27022355..27932498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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