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    Xxylt1 xyloside xylosyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 268880, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xxylt1provided by MGI
    Official Full Name
    xyloside xylosyltransferase 1provided by MGI
    Primary source
    MGI:MGI:2146443
    See related
    Ensembl:ENSMUSG00000047434 AllianceGenome:MGI:2146443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables UDP-xylosyltransferase activity and manganese ion binding activity. Involved in O-glycan processing. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human XXYLT1 (xyloside xylosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 12.5), ovary adult (RPKM 12.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Xxylt1 in Genome Data Viewer
    Location:
    16 B2; 16 21.34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30774165..30900250, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (30955347..31081432, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40599 Neighboring gene predicted gene, 25375 Neighboring gene predicted gene, 46565 Neighboring gene STARR-seq mESC enhancer starr_40600 Neighboring gene STARR-seq mESC enhancer starr_40602 Neighboring gene STARR-positive B cell enhancer ABC_E10899 Neighboring gene predicted gene 15742 Neighboring gene predicted gene, 41440 Neighboring gene STARR-positive B cell enhancer ABC_E7437 Neighboring gene STARR-positive B cell enhancer ABC_E11610 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:31081520-31081703 Neighboring gene predicted gene, 46554 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 Neighboring gene zinc finger protein 161 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40608 Neighboring gene STARR-positive B cell enhancer ABC_E4163 Neighboring gene STARR-positive B cell enhancer ABC_E7438 Neighboring gene predicted gene, 52237 Neighboring gene predicted gene, 41442

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism. Yu H, et al. Nat Chem Biol, 2015 Nov. PMID 26414444, Free PMC Article
    2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC19367

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-xylosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-xylosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables xylosyl alpha-1,3-xylosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xylosyl alpha-1,3-xylosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables xylosyl alpha-1,3-xylosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in O-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in O-glycan processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in O-glycan processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in O-glycan processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    xyloside xylosyltransferase 1
    Names
    UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase
    NP_941028.2
    XP_006522263.1
    XP_030104996.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198626.3 → NP_941028.2  xyloside xylosyltransferase 1

      See identical proteins and their annotated locations for NP_941028.2

      Status: VALIDATED

      Source sequence(s)
      AC090430, AC126280
      Consensus CDS
      CCDS49822.1
      UniProtKB/Swiss-Prot
      E9QL73, Q3TLX5, Q3U4G3, Q8K2I0
      Related
      ENSMUSP00000050246.8, ENSMUST00000055389.9
      Conserved Domains (2) summary
      COG1442
      Location:216 → 352
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
      cl11394
      Location:117 → 382
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      30774165..30900250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249136.2 → XP_030104996.1  xyloside xylosyltransferase 1 isoform X1

      Conserved Domains (1) summary
      cl11394
      Location:9 → 196
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_006522200.2 → XP_006522263.1  xyloside xylosyltransferase 1 isoform X1

      Conserved Domains (1) summary
      cl11394
      Location:9 → 196
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U4G3.2 GenPept UniProtKB/Swiss-Prot:Q3U4G3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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