Miga1 mitoguardin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Miga1provided by MGI
Official Full Name: mitoguardin 1provided by MGI
Primary source: MGI:MGI:1924567
See related: Ensembl:ENSMUSG00000054942 AllianceGenome:MGI:1924567
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mita1; Fam73a; A930038D06; C030011O14Rik
Summary: Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Predicted to be located in mitochondrion and plasma membrane. Is expressed in brain; metanephros; spinal cord; and testis. Orthologous to human MIGA1 (mitoguardin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cerebellum adult (RPKM 11.0), cortex adult (RPKM 9.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H3; 3 77.1 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (151979096..152046073, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (152273459..152340436, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ovarian phenotypes of these mice suggested that MIGA1/2 proteins play an important role in ovulation and ovarian steroidogenesis. In vivo and in vitro analyses of Miga1/2-knockout granulosa cells showed severe defects in luteinization and steroidogenesis and disordered mitochondrial morphology and function in response to gonadotropins.
Title: Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation.
Data indicate that mitoguardin (Miga) knoskout Miga1/2-/- females show greatly reduced quality of oocytes and early embryos and are subfertile.
Title: Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions.
Propose that MIGA1/2 proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD.
Title: Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fusion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitoguardin 1

Names: family with sequence similarity 73, member A; protein FAM73A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162375.1 → NP_001155847.1 mitoguardin 1 isoform 2

See identical proteins and their annotated locations for NP_001155847.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two exons in the coding region compared to variant 1. The encoded isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC123075, AK045347, AK085017

Consensus CDS

CCDS51096.1

UniProtKB/Swiss-Prot

Q4QQM5

Related

ENSMUSP00000068261.7, ENSMUST00000068243.11

Conserved Domains (1) summary

pfam10265
Location:27 → 507

DUF2217; Uncharacterized conserved protein (DUF2217)
NM_174868.4 → NP_777357.2 mitoguardin 1 isoform 1

See identical proteins and their annotated locations for NP_777357.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC123075, AK085017, BC098205

Consensus CDS

CCDS17916.1

UniProtKB/Swiss-Prot

Q4QQM5, Q8BR91, Q8C3S6, Q8C8P4

UniProtKB/TrEMBL

B2RRB9

Related

ENSMUSP00000072836.7, ENSMUST00000073089.13

Conserved Domains (1) summary

pfam10265
Location:27 → 571

DUF2217; Uncharacterized conserved protein (DUF2217)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

151979096..152046073 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163015.1 → XP_036018908.1 mitoguardin 1 isoform X3

Conserved Domains (1) summary

pfam10265
Location:2 → 306

Miga; Mitoguardin
XM_011240070.4 → XP_011238372.1 mitoguardin 1 isoform X1

Related

ENSMUSP00000143238.2, ENSMUST00000199334.5

Conserved Domains (1) summary

pfam10265
Location:27 → 489

Miga; Mitoguardin
XM_036163016.1 → XP_036018909.1 mitoguardin 1 isoform X4

Conserved Domains (1) summary

pfam10265
Location:27 → 301

Miga; Mitoguardin
XM_036163014.1 → XP_036018907.1 mitoguardin 1 isoform X2

Conserved Domains (1) summary

pfam10265
Location:27 → 339

Miga; Mitoguardin