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    Plpp5 phospholipid phosphatase 5 [ Mus musculus (house mouse) ]

    Gene ID: 71910, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plpp5provided by MGI
    Official Full Name
    phospholipid phosphatase 5provided by MGI
    Primary source
    MGI:MGI:1919160
    See related
    Ensembl:ENSMUSG00000031570 AllianceGenome:MGI:1919160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ppapdc1; Ppapdc1b; 1810019D05Rik; 2310022A04Rik
    Summary
    Predicted to enable diacylglycerol diphosphate phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation and phospholipid metabolic process. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human PLPP5 (phospholipid phosphatase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 43.6), colon adult (RPKM 40.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plpp5 in Genome Data Viewer
    Location:
    8 A2; 8 14.17 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26210052..26214914)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25720043..25724887)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8232 Neighboring gene STARR-positive B cell enhancer ABC_E2860 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E6630 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26722454-26722679 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26728550-26728737 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene predicted gene, 24992 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26830817-26831000 Neighboring gene DDHD domain containing 2 Neighboring gene predicted gene, 17484 Neighboring gene BCL2-associated athanogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins. Trezise S, et al. Int J Mol Sci, 2018 Jul 24. PMID 30042348, Free PMC Article
    2. An Ideal PPAR Response Element Bound to and Activated by PPARα. Tzeng J, et al. PLoS One, 2015. PMID 26241474, Free PMC Article
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables diacylglycerol diphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables diacylglycerol diphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid phosphatase 5
    Names
    phosphatidate phosphatase PPAPDC1B
    phosphatidic acid phosphatase type 2 domain containing 1
    phosphatidic acid phosphatase type 2 domain containing 1B
    phosphatidic acid phosphatase type 2 domain-containing protein 1B
    NP_001280632.1
    NP_082276.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293703.1 → NP_001280632.1  phospholipid phosphatase 5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' end compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA184457, BB857717, BC062173, BE646843
      Consensus CDS
      CCDS80868.1
      UniProtKB/TrEMBL
      Q6P6K4
      Related
      ENSMUSP00000122437.2, ENSMUST00000139836.8
      Conserved Domains (1) summary
      cd03390
      Location:39 → 207
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    2. NM_028000.1 → NP_082276.1  phospholipid phosphatase 5 isoform 1

      See identical proteins and their annotated locations for NP_082276.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA184457, CO044265, DV661598
      Consensus CDS
      CCDS40306.1
      UniProtKB/Swiss-Prot
      Q3UMZ3, Q4KL19
      Related
      ENSMUSP00000067035.9, ENSMUST00000068916.16
      Conserved Domains (1) summary
      cd03390
      Location:39 → 227
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    RNA

    1. NR_121642.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA184457, BC062173
      Related
      ENSMUST00000124764.8

    2. NR_121643.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses alternate splice junctions at the 5' end of one exon and 3' end of another exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA184457, BC062173
      Related
      ENSMUST00000145678.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      26210052..26214914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003947335.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UMZ3.1 GenPept UniProtKB/Swiss-Prot:Q3UMZ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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