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    Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 [ Mus musculus (house mouse) ]

    Gene ID: 66414, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndufa12provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit A12provided by MGI
    Primary source
    MGI:MGI:1913664
    See related
    Ensembl:ENSMUSG00000020022 AllianceGenome:MGI:1913664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CIB17.2; CI-B17.2; 2410011G03Rik
    Summary
    Predicted to be involved in mitochondrial ATP synthesis coupled electron transport and response to oxidative stress. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and skeleton. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 23. Orthologous to human NDUFA12 (NADH:ubiquinone oxidoreductase subunit A12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 187.5), kidney adult (RPKM 133.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ndufa12 in Genome Data Viewer
    Location:
    10 C2; 10 48.83 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (94034897..94057302)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (94199035..94221440)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene B-cell CLL/lymphoma 9-like pseudogene Neighboring gene nuclear receptor subfamily 2, group C, member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93661580-93661763 Neighboring gene predicted gene, 26122 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93697972-93698081 Neighboring gene predicted gene, 32749 Neighboring gene STARR-seq mESC enhancer starr_27596 Neighboring gene predicted gene 4792

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC7999, MGC107642

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytosol  
    is_active_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    part_of respiratory chain complex I  
    part_of respiratory chain complex I PubMed 
    part_of respiratory chain complex I  
    part_of respiratory chain complex I  

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
    Names
    13kDa differentiation-associated protein
    NADH-ubiquinone oxidoreductase subunit B17.2
    complex I-B17.2
    NP_001351620.1
    NP_079827.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364691.1NP_001351620.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138026
      UniProtKB/TrEMBL
      F6RBR6
      Related
      ENSMUSP00000119625.3, ENSMUST00000135292.3
      Conserved Domains (1) summary
      pfam05071
      Location:3785
      NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12
    2. NM_025551.4NP_079827.3  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC138026
      Consensus CDS
      CCDS24132.2
      UniProtKB/Swiss-Prot
      Q3TIA0, Q7TMF3
      UniProtKB/TrEMBL
      Q8BME2, Q9CQ83
      Related
      ENSMUSP00000020209.10, ENSMUST00000020209.16
      Conserved Domains (1) summary
      pfam05071
      Location:37116
      NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      94034897..94057302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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