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    Clca3a2 chloride channel accessory 3A2 [ Mus musculus (house mouse) ]

    Gene ID: 80797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clca3a2provided by MGI
    Official Full Name
    chloride channel accessory 3A2provided by MGI
    Primary source
    MGI:MGI:1931471
    See related
    Ensembl:ENSMUSG00000028262 AllianceGenome:MGI:1931471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clca2
    Summary
    Predicted to enable intracellularly calcium-gated chloride channel activity. Acts upstream of or within anoikis and extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; heart; and integumental system. Orthologous to human CLCA3P (chloride channel accessory 3, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 6.3), mammary gland adult (RPKM 6.1) and 11 other tissues See more
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    Genomic context

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    See Clca3a2 in Genome Data Viewer
    Location:
    3 H2; 3 69.12 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144486340..144525385, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (144780581..144819623, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene BCL2/adenovirus E1B interacting protein 3 pseudogene Neighboring gene chloride channel accessory 3A1 Neighboring gene predicted gene, 34866 Neighboring gene nuclear receptor subfamily 5, group A, member 2 pseudogene Neighboring gene chloride channel accessory 3B Neighboring gene STARR-seq mESC enhancer starr_09185 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 pseudogene Neighboring gene predicted gene, 57838

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Induction of mouse Ca(2+)-sensitive chloride channel 2 gene during involution of mammary gland. Lee D, et al. Biochem Biophys Res Commun, 1999 Nov 2. PMID 10544033
    2. Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction. Yang W, et al. Cell Chem Biol, 2023 Oct 19. PMID 37442135
    3. Tumor suppression by a proapoptotic calcium-activated chloride channel in mammary epithelium. Elble RC, et al. J Biol Chem, 2001 Nov 2. PMID 11483609
    4. Real-time RT-PCR quantitation of mCLCA1 and mCLCA2 reveals differentially regulated expression in pre- and postnatal murine tissues. Leverkoehne I, et al. Histochem Cell Biol, 2002 Jul. PMID 12122442
    5. Cellular distribution and subcellular localization of mCLCA1/2 in murine gastrointestinal epithelia. Roussa E, et al. J Histochem Cytochem, 2010 Jul. PMID 20385786, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The apical membrane localization and overall distribution pattern of mCLCA2 favor a transmembrane protein implicated in transepithelial ion transport and protein secretion.
      Title: Cellular distribution and subcellular localization of mCLCA1/2 in murine gastrointestinal epithelia.
    2. Quantitation of mCLCA1 and mCLCA2 in 19 pre- and 44 postnatal murine tissues reveals differentially regulated expression in pre- and postnatal murine tissues
      Title: Real-time RT-PCR quantitation of mCLCA1 and mCLCA2 reveals differentially regulated expression in pre- and postnatal murine tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables intracellularly calcium-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anoikis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chloride transport ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chloride channel calcium activated 3A2
    Names
    chloride channel calcium activated 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030601.3 → NP_085104.1  chloride channel calcium activated 3A2 precursor

      See identical proteins and their annotated locations for NP_085104.1

      Status: VALIDATED

      Source sequence(s)
      AC137128, AF115852
      Consensus CDS
      CCDS17887.1
      UniProtKB/TrEMBL
      Q9EQR4, Q9R070
      Related
      ENSMUSP00000029929.8, ENSMUST00000029929.12
      Conserved Domains (3) summary
      TIGR00868
      Location:1 → 865
      hCaCC; calcium-activated chloride channel protein 1
      cd00198
      Location:307 → 461
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl19929
      Location:529 → 569
      A2M_N; MG2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      144486340..144525385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319812.3 → XP_017175301.1  chloride channel calcium activated 3A2 isoform X2

      UniProtKB/TrEMBL
      Q9R070
      Conserved Domains (1) summary
      TIGR00868
      Location:15 → 802
      hCaCC; calcium-activated chloride channel protein 1

    2. XM_017319811.3 → XP_017175300.1  chloride channel calcium activated 3A2 isoform X1

      UniProtKB/TrEMBL
      Q9R070
      Conserved Domains (1) summary
      TIGR00868
      Location:15 → 810
      hCaCC; calcium-activated chloride channel protein 1

    3. XM_006502346.4 → XP_006502409.1  chloride channel calcium activated 3A2 isoform X3

      Conserved Domains (1) summary
      TIGR00868
      Location:15 → 579
      hCaCC; calcium-activated chloride channel protein 1
    Nucleotide Protein Strain
    Heading Accession and Version

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