Rfk riboflavin kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rfkprovided by MGI
Official Full Name: riboflavin kinaseprovided by MGI
Primary source: MGI:MGI:1914688
See related: Ensembl:ENSMUSG00000024712 AllianceGenome:MGI:1914688
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KOI-4; 0610038L10Rik
Summary: Predicted to enable riboflavin kinase activity. Involved in flavin adenine dinucleotide biosynthetic process and riboflavin metabolic process. Acts upstream of or within positive regulation of NAD(P)H oxidase activity and reactive oxygen species metabolic process. Located in mitochondrion. Is active in cytosol. Is expressed in several structures, including alimentary system; facial bone primordium; heart; respiratory system; and urinary system. Orthologous to human RFK (riboflavin kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in duodenum adult (RPKM 356.9), adrenal adult (RPKM 314.6) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 B; 19 12.82 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (17371407..17378713)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (17394043..17401349)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of Rfk combined with a riboflavin-deficient diet altered the CRY levels in mouse liver and the expression profiles of clock and clock-controlled genes (especially those related to metabolism including glucose homeostasis).
Title: FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice.
results suggest that TNF, through the activation of RFK, enhances the incorporation of FAD in NADPH oxidase enzymes, a critical step for the assembly and activation of NADPH oxidase
Title: Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF031381 (e-PCR)
- UniSTS:160811

RH129140 (e-PCR)
- UniSTS:212448

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables riboflavin kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables riboflavin kinase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables riboflavin kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables riboflavin kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in FMN biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in FMN biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in flavin adenine dinucleotide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of NAD(P)H oxidase activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of NAD(P)H oxidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in riboflavin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in riboflavin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in riboflavin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in riboflavin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in riboflavin metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: riboflavin kinase

Names: ATP:riboflavin 5'-phosphotransferase; flavokinase

NP_062310.1

EC 2.7.1.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.