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    ZDHHC23 zinc finger DHHC-type palmitoyltransferase 23 [ Homo sapiens (human) ]

    Gene ID: 254887, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZDHHC23provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 23provided by HGNC
    Primary source
    HGNC:HGNC:28654
    See related
    Ensembl:ENSG00000184307 MIM:617334; AllianceGenome:HGNC:28654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NIDD; DHHC-23
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in protein localization to plasma membrane and protein palmitoylation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 5.9), colon (RPKM 3.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZDHHC23 in Genome Data Viewer
    Location:
    3q13.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (113947901..113979508)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (116669165..116719588)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113666748..113682220)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 1C Neighboring gene CTDNEP1 pseudogene 1 Neighboring gene VPS26A pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:113666278-113666778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14613 Neighboring gene coiled-coil domain containing 191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20265 Neighboring gene ATP5PB pseudogene 8 Neighboring gene uncharacterized LOC105374048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20267

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Ellinghaus D, et al. Am J Hum Genet, 2012 Apr 6. PMID 22482804, Free PMC Article
    2. NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity. Saitoh F, et al. J Biol Chem, 2004 Jul 9. PMID 15105416
    3. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. Tian L, et al. J Biol Chem, 2012 Apr 27. PMID 22399288, Free PMC Article
    4. DHHC protein family targets different subsets of glioma stem cells in specific niches. Chen X, et al. J Exp Clin Cancer Res, 2019 Jan 18. PMID 30658672, Free PMC Article
    5. Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107410

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC42530

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC23
    Names
    zinc finger DHHC domain-containing protein 23
    zinc finger DHHC-type containing 23
    NP_001307395.1
    NP_001307396.1
    NP_001307397.1
    NP_001350881.1
    NP_775841.2
    XP_005247326.1
    XP_005247327.1
    XP_006713625.1
    XP_011510920.1
    XP_011510921.1
    XP_016861573.1
    XP_016861575.1
    XP_016861576.1
    XP_047303838.1
    XP_047303839.1
    XP_047303841.1
    XP_047303842.1
    XP_047303843.1
    XP_047303844.1
    XP_047303846.1
    XP_047303847.1
    XP_047303848.1
    XP_047303849.1
    XP_047303850.1
    XP_047303851.1
    XP_054201962.1
    XP_054201963.1
    XP_054201964.1
    XP_054201965.1
    XP_054201966.1
    XP_054201967.1
    XP_054201968.1
    XP_054201969.1
    XP_054201970.1
    XP_054201971.1
    XP_054201972.1
    XP_054201973.1
    XP_054201974.1
    XP_054201975.1
    XP_054201976.1
    XP_054201977.1
    XP_054201978.1
    XP_054201979.1
    XP_054201980.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320466.2 → NP_001307395.1  palmitoyltransferase ZDHHC23 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC128687
      Consensus CDS
      CCDS93341.1
      UniProtKB/TrEMBL
      A0A1W2PRJ8, B3KXB3
      Related
      ENSP00000492287.2, ENST00000638807.2
      Conserved Domains (2) summary
      pfam01529
      Location:258 → 384
      zf-DHHC; DHHC palmitoyltransferase
      pfam03203
      Location:96 → 151
      MerC; MerC mercury resistance protein

    2. NM_001320467.2 → NP_001307396.1  palmitoyltransferase ZDHHC23 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC128687
      Consensus CDS
      CCDS93341.1
      UniProtKB/TrEMBL
      A0A1W2PRJ8, B3KXB3
      Conserved Domains (2) summary
      pfam01529
      Location:258 → 384
      zf-DHHC; DHHC palmitoyltransferase
      pfam03203
      Location:96 → 151
      MerC; MerC mercury resistance protein

    3. NM_001320468.2 → NP_001307397.1  palmitoyltransferase ZDHHC23 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC128687
      UniProtKB/TrEMBL
      B3KXB3
      Conserved Domains (2) summary
      pfam01529
      Location:258 → 381
      zf-DHHC; DHHC palmitoyltransferase
      pfam03203
      Location:96 → 151
      MerC; MerC mercury resistance protein

    4. NM_001363952.1 → NP_001350881.1  palmitoyltransferase ZDHHC23 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC128687
      Consensus CDS
      CCDS87122.1
      UniProtKB/TrEMBL
      B3KXB3, E9PAP7
      Conserved Domains (2) summary
      pfam01529
      Location:258 → 384
      zf-DHHC; DHHC palmitoyltransferase
      cl03934
      Location:96 → 151
      MerC; MerC mercury resistance protein

    5. NM_173570.5 → NP_775841.2  palmitoyltransferase ZDHHC23 isoform c

      See identical proteins and their annotated locations for NP_775841.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and the 3' structure, resulting in a distinct 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus, and is shorter, compared to isoform a.
      Source sequence(s)
      AC128687, AF131818, AK127996, BC035230, CA389626
      Consensus CDS
      CCDS33827.1
      UniProtKB/Swiss-Prot
      D3DN76, Q8IYP9
      UniProtKB/TrEMBL
      B3KXV3
      Related
      ENSP00000330485.3, ENST00000330212.7
      Conserved Domains (2) summary
      pfam01529
      Location:258 → 384
      zf-DHHC; DHHC palmitoyltransferase
      pfam03203
      Location:96 → 151
      MerC; MerC mercury resistance protein

    RNA

    1. NR_135271.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has a different 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5' most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC128687, AK127025, BC035230, CA389626

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      113947901..113979508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447885.1 → XP_047303841.1  palmitoyltransferase ZDHHC23 isoform X3

    2. XM_006713562.4 → XP_006713625.1  palmitoyltransferase ZDHHC23 isoform X3

      UniProtKB/TrEMBL
      B3KXB3
      Conserved Domains (2) summary
      pfam01529
      Location:258 → 384
      zf-DHHC; DHHC palmitoyltransferase
      pfam03203
      Location:96 → 151
      MerC; MerC mercury resistance protein

    3. XM_047447886.1 → XP_047303842.1  palmitoyltransferase ZDHHC23 isoform X3

    4. XM_047447887.1 → XP_047303843.1  palmitoyltransferase ZDHHC23 isoform X4

      UniProtKB/TrEMBL
      E9PAP7

    5. XM_047447883.1 → XP_047303839.1  palmitoyltransferase ZDHHC23 isoform X2

    6. XM_047447890.1 → XP_047303846.1  palmitoyltransferase ZDHHC23 isoform X5

    7. XM_047447895.1 → XP_047303851.1  palmitoyltransferase ZDHHC23 isoform X10

    8. XM_047447882.1 → XP_047303838.1  palmitoyltransferase ZDHHC23 isoform X1

      UniProtKB/TrEMBL
      A0A1W2PRJ8

    9. XM_047447891.1 → XP_047303847.1  palmitoyltransferase ZDHHC23 isoform X6

      UniProtKB/Swiss-Prot
      D3DN76, Q8IYP9

    10. XM_047447893.1 → XP_047303849.1  palmitoyltransferase ZDHHC23 isoform X8

    11. XM_011512619.2 → XP_011510921.1  palmitoyltransferase ZDHHC23 isoform X4

      UniProtKB/TrEMBL
      B3KXB3, E9PAP7
      Related
      ENSP00000420251.1, ENST00000478793.1
      Conserved Domains (2) summary
      pfam01529
      Location:258 → 384
      zf-DHHC; DHHC palmitoyltransferase
      cl03934
      Location:96 → 151
      MerC; MerC mercury resistance protein

    12. XM_005247269.2 → XP_005247326.1  palmitoyltransferase ZDHHC23 isoform X6

      See identical proteins and their annotated locations for XP_005247326.1

      UniProtKB/Swiss-Prot
      D3DN76, Q8IYP9
      UniProtKB/TrEMBL
      B3KXV3
      Related
      ENSP00000417840.1, ENST00000498275.5
      Conserved Domains (2) summary
      pfam01529
      Location:258 → 384
      zf-DHHC; DHHC palmitoyltransferase
      pfam03203
      Location:96 → 151
      MerC; MerC mercury resistance protein

    13. XM_017006087.2 → XP_016861576.1  palmitoyltransferase ZDHHC23 isoform X5

      UniProtKB/TrEMBL
      B3KXB3

    14. XM_017006086.2 → XP_016861575.1  palmitoyltransferase ZDHHC23 isoform X7

      UniProtKB/TrEMBL
      B3KXV3

    15. XM_011512618.3 → XP_011510920.1  palmitoyltransferase ZDHHC23 isoform X1

      See identical proteins and their annotated locations for XP_011510920.1

      UniProtKB/TrEMBL
      A0A1W2PRJ8, B3KXB3
      Conserved Domains (2) summary
      pfam01529
      Location:258 → 384
      zf-DHHC; DHHC palmitoyltransferase
      pfam03203
      Location:96 → 151
      MerC; MerC mercury resistance protein

    16. XM_047447888.1 → XP_047303844.1  palmitoyltransferase ZDHHC23 isoform X4

      UniProtKB/TrEMBL
      E9PAP7

    17. XM_047447892.1 → XP_047303848.1  palmitoyltransferase ZDHHC23 isoform X6

      UniProtKB/Swiss-Prot
      D3DN76, Q8IYP9

    18. XM_017006084.2 → XP_016861573.1  palmitoyltransferase ZDHHC23 isoform X2

      UniProtKB/TrEMBL
      B3KXB3
      Conserved Domains (2) summary
      pfam01529
      Location:258 → 381
      zf-DHHC; DHHC palmitoyltransferase
      pfam03203
      Location:96 → 151
      MerC; MerC mercury resistance protein

    19. XM_005247270.4 → XP_005247327.1  palmitoyltransferase ZDHHC23 isoform X8

      Conserved Domains (1) summary
      pfam01529
      Location:97 → 223
      zf-DHHC; DHHC palmitoyltransferase

    20. XM_047447894.1 → XP_047303850.1  palmitoyltransferase ZDHHC23 isoform X9

    RNA

    1. XR_001740081.2 RNA Sequence

    2. XR_007095654.1 RNA Sequence

    3. XR_924119.2 RNA Sequence

    4. XR_007095655.1 RNA Sequence

    5. XR_007095657.1 RNA Sequence

    6. XR_007095656.1 RNA Sequence

    7. XR_007095658.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      116669165..116719588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345992.1 → XP_054201967.1  palmitoyltransferase ZDHHC23 isoform X3

    2. XM_054345991.1 → XP_054201966.1  palmitoyltransferase ZDHHC23 isoform X3

    3. XM_054345996.1 → XP_054201971.1  palmitoyltransferase ZDHHC23 isoform X4

      UniProtKB/TrEMBL
      E9PAP7

    4. XM_054345989.1 → XP_054201964.1  palmitoyltransferase ZDHHC23 isoform X2

    5. XM_054345999.1 → XP_054201974.1  palmitoyltransferase ZDHHC23 isoform X5

    6. XM_054346005.1 → XP_054201980.1  palmitoyltransferase ZDHHC23 isoform X10

    7. XM_054345988.1 → XP_054201963.1  palmitoyltransferase ZDHHC23 isoform X1

      UniProtKB/TrEMBL
      A0A1W2PRJ8

    8. XM_054346000.1 → XP_054201975.1  palmitoyltransferase ZDHHC23 isoform X6

      UniProtKB/Swiss-Prot
      D3DN76, Q8IYP9

    9. XM_054346002.1 → XP_054201977.1  palmitoyltransferase ZDHHC23 isoform X8

    10. XM_054345993.1 → XP_054201968.1  palmitoyltransferase ZDHHC23 isoform X4

      UniProtKB/TrEMBL
      E9PAP7

    11. XM_054345995.1 → XP_054201970.1  palmitoyltransferase ZDHHC23 isoform X6

      UniProtKB/Swiss-Prot
      D3DN76, Q8IYP9

    12. XM_054345994.1 → XP_054201969.1  palmitoyltransferase ZDHHC23 isoform X5

    13. XM_054345998.1 → XP_054201973.1  palmitoyltransferase ZDHHC23 isoform X7

    14. XM_054345987.1 → XP_054201962.1  palmitoyltransferase ZDHHC23 isoform X1

      UniProtKB/TrEMBL
      A0A1W2PRJ8

    15. XM_054345997.1 → XP_054201972.1  palmitoyltransferase ZDHHC23 isoform X4

      UniProtKB/TrEMBL
      E9PAP7

    16. XM_054346001.1 → XP_054201976.1  palmitoyltransferase ZDHHC23 isoform X6

      UniProtKB/Swiss-Prot
      D3DN76, Q8IYP9

    17. XM_054345990.1 → XP_054201965.1  palmitoyltransferase ZDHHC23 isoform X2

    18. XM_054346003.1 → XP_054201978.1  palmitoyltransferase ZDHHC23 isoform X8

    19. XM_054346004.1 → XP_054201979.1  palmitoyltransferase ZDHHC23 isoform X9

    RNA

    1. XR_008486687.1 RNA Sequence

    2. XR_008486688.1 RNA Sequence

    3. XR_008486686.1 RNA Sequence

    4. XR_008486685.1 RNA Sequence

    5. XR_008486690.1 RNA Sequence

    6. XR_008486683.1 RNA Sequence

    7. XR_008486689.1 RNA Sequence

    8. XR_008486684.1 RNA Sequence

    9. XR_008486692.1 RNA Sequence

    10. XR_008486691.1 RNA Sequence

    11. XR_008486693.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IYP9.3 GenPept UniProtKB/Swiss-Prot:Q8IYP9

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