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    PZP PZP alpha-2-macroglobulin like [ Homo sapiens (human) ]

    Gene ID: 5858, updated on 3-Dec-2024

    Summary

    Official Symbol
    PZPprovided by HGNC
    Official Full Name
    PZP alpha-2-macroglobulin likeprovided by HGNC
    Primary source
    HGNC:HGNC:9750
    See related
    Ensembl:ENSG00000126838 MIM:176420; AllianceGenome:HGNC:9750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPAMD6
    Summary
    The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]
    Expression
    Biased expression in liver (RPKM 5.3), endometrium (RPKM 1.0) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PZP in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (9136472..9208395, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (9131038..9191012, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (9301436..9360991, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene killer cell lectin like receptor G1 Neighboring gene keratin 17 pseudogene 8 Neighboring gene BTG anti-proliferation factor 1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:9322697-9323208 Neighboring gene TPT1 pseudogene 12 Neighboring gene microRNA 1244-3 Neighboring gene alpha-2-macroglobulin pseudogene 1 Neighboring gene prothymosin alpha pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    pregnancy zone protein
    Names
    C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
    Pregnancy zone protein
    pregnancy-zone protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052998.1 RefSeqGene

      Range
      4976..64531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002864.3NP_002855.2  pregnancy zone protein precursor

      See identical proteins and their annotated locations for NP_002855.2

      Status: REVIEWED

      Source sequence(s)
      AC010175, DB040351, X54380
      Consensus CDS
      CCDS8600.1
      UniProtKB/Swiss-Prot
      A6ND27, P20742, Q15273, Q2NKL2, Q7M4N7
      UniProtKB/TrEMBL
      B2R950
      Related
      ENSP00000261336.2, ENST00000261336.7
      Conserved Domains (7) summary
      cd02897
      Location:9641270
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:744834
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128220
      A2M_N; MG2 domain
      pfam05326
      Location:796891
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:13821469
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:10161272
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:457602
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      9136472..9208395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429274.1XP_047285230.1  pregnancy zone protein isoform X3

      UniProtKB/TrEMBL
      B2R950
    2. XM_017019763.2XP_016875252.1  pregnancy zone protein isoform X1

      UniProtKB/TrEMBL
      B2R950
      Conserved Domains (7) summary
      cd02897
      Location:9641270
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:744834
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128220
      A2M_N; MG2 domain
      pfam05326
      Location:796891
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:13821464
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:10161272
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:457602
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    3. XM_047429276.1XP_047285232.1  pregnancy zone protein isoform X8

    4. XM_047429275.1XP_047285231.1  pregnancy zone protein isoform X7

    5. XM_017019764.2XP_016875253.1  pregnancy zone protein isoform X2

      UniProtKB/TrEMBL
      B2R950
    6. XM_024449111.1XP_024304879.1  pregnancy zone protein isoform X4

      UniProtKB/TrEMBL
      B2R950
      Conserved Domains (5) summary
      cd02897
      Location:7501056
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:613700
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:1289
      A2M_N; MG2 domain
      pfam07677
      Location:11681255
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:324472
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    7. XM_011520806.2XP_011519108.1  pregnancy zone protein isoform X5

      Conserved Domains (5) summary
      pfam00207
      Location:744834
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128220
      A2M_N; MG2 domain
      pfam05326
      Location:796891
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07703
      Location:457602
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      cl08267
      Location:9641045
      ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
    8. XM_011520807.3XP_011519109.1  pregnancy zone protein isoform X6

      Conserved Domains (3) summary
      pfam00207
      Location:744830
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128220
      A2M_N; MG2 domain
      pfam07703
      Location:457602
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RNA

    1. XR_001748834.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      9131038..9191012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008488655.1 RNA Sequence

    2. XR_008488654.1 RNA Sequence

    3. XR_008488653.1 RNA Sequence