FDX1 ferredoxin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FDX1provided by HGNC
Official Full Name: ferredoxin 1provided by HGNC
Primary source: HGNC:HGNC:3638
See related: Ensembl:ENSG00000137714 MIM:103260; AllianceGenome:HGNC:3638
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADX; FDX; LOH11CR1D
Summary: This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011]
Expression: Biased expression in adrenal (RPKM 178.6), kidney (RPKM 13.5) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q22.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (110429331..110464884)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (110439522..110475104)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (110300672..110335608)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production.
Title: FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production.
Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma progression through activation of the GPRIN2 signaling pathway.
Title: Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma progression through activation of the GPRIN2 signaling pathway.
METTL3 promotes non-small-cell lung cancer growth and metastasis by inhibiting FDX1 through copper death-associated pri-miR-21-5p maturation.
Title: METTL3 promotes non-small-cell lung cancer growth and metastasis by inhibiting FDX1 through copper death-associated pri-miR-21-5p maturation.
Systematic analysis based on the cuproptosis-related genes identifies ferredoxin 1 as an immune regulator and therapeutic target for glioblastoma.
Title: Systematic analysis based on the cuproptosis-related genes identifies ferredoxin 1 as an immune regulator and therapeutic target for glioblastoma.
Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by NMR; modulation by cytochrome P450 substrate and by truncation of the C-terminal tail.
Title: Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by NMR; modulation by cytochrome P450 substrate and by truncation of the C-terminal tail.
Prognostic and immunological role of FDX1 in pan-cancer: an in-silico analysis.
Title: Prognostic and immunological role of FDX1 in pan-cancer: an in-silico analysis.
Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.
Title: Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.
FDX1 regulates cellular protein lipoylation through direct binding to LIAS.
Title: FDX1 regulates cellular protein lipoylation through direct binding to LIAS.
Integrated analyses reveal the prognostic, immunological features and mechanisms of cuproptosis critical mediator gene FDX1 in KIRC.
Title: Integrated analyses reveal the prognostic, immunological features and mechanisms of cuproptosis critical mediator gene FDX1 in KIRC.
Expression of Ferredoxin1 in cisplatin-resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin.
Title: Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Heritability and genetic association analysis of cognition in the&#x000a0;Diabetes Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH67935 (e-PCR)
- UniSTS:92464

D11S1300 (e-PCR), detects polymorphism
- UniSTS:87091

GDB:197839 (e-PCR)
- UniSTS:155959

G64373 (e-PCR)
- UniSTS:163669

D11S1300 (e-PCR), detects polymorphism
- UniSTS:30565

A004I10 (e-PCR)
- UniSTS:62837

RH28627 (e-PCR)
- UniSTS:85380

D4S3130 (e-PCR)
- UniSTS:41878

RH36031 (e-PCR)
- UniSTS:30112

RH69129 (e-PCR)
- UniSTS:85994

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables iron ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in P450-containing electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to forskolin	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	TAS Traceable Author Statement more info
located_in mitochondrion	HTP more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: adrenodoxin, mitochondrial

Names: adrenal ferredoxin; hepatoredoxin; mitochondrial adrenodoxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004109.5 → NP_004100.1 adrenodoxin, mitochondrial precursor

See identical proteins and their annotated locations for NP_004100.1

Status: REVIEWED

Source sequence(s)

AA505582, BC010284, CN333249, DB459133

Consensus CDS

CCDS8344.1

UniProtKB/Swiss-Prot

B0YJ14, P10109, Q53YD6

Related

ENSP00000260270.2, ENST00000260270.3

Conserved Domains (1) summary

cl00159
Location:67 → 168

fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...