U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CNR1 cannabinoid receptor 1 [ Homo sapiens (human) ]

    Gene ID: 1268, updated on 3-Dec-2024

    Summary

    Official Symbol
    CNR1provided by HGNC
    Official Full Name
    cannabinoid receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:2159
    See related
    Ensembl:ENSG00000118432 MIM:114610; AllianceGenome:HGNC:2159
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
    Summary
    This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
    Expression
    Biased expression in brain (RPKM 6.2), fat (RPKM 2.7) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CNR1 in Genome Data Viewer
    Location:
    6q15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (88139864..88167349, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (89348358..89375841, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (88849583..88877068, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986541 Neighboring gene sperm acrosome associated 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:88834755-88835954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24814 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:88893112-88893675 Neighboring gene MPRA-validated peak5945 silencer Neighboring gene ribosomal protein S14 pseudogene 9 Neighboring gene ACTB pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env CB1 or CB2 receptor agonists significantly inhibit HIV-1 gp120-induced decrease proliferation and increase apoptosis of human neural progenitor cells (hNPCs), indicating that CB1 or CB2 receptors are required for the effects of gp120 on hNPCs PubMed
    env HIV-1 gp120 downregulates expression of cannabinoid receptor 1 (CB1) in human brain micro vascular endothelial cells (HBMEC) PubMed
    Tat tat HIV-1 Tat upregulates the expression of CB1 and CB2 cannabinoid receptors in retinal cells, which is suppressed by endocannabinoids, N-arachidonoylethanolamide and 2-arachidonoylglycerol PubMed
    tat CB1 and CB2 endocannabinoid receptors are involved in HIV-1 Tat-induced cleavage of PARP1 and CASP3 in retinal cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cannabinoid receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in axonal fasciculation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cannabinoid signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maternal process involved in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mast cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of serotonin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of acute inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fever generation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of penile erection IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrograde trans-synaptic signaling by endocannabinoid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cannabinoid receptor 1
    Names
    cannabinoid receptor 1 (brain)
    central cannabinoid receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160226.3NP_001153698.1  cannabinoid receptor 1 isoform a

      See identical proteins and their annotated locations for NP_001153698.1

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      Consensus CDS
      CCDS5015.1
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
      Conserved Domains (1) summary
      cd15340
      Location:117408
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001160258.3NP_001153730.1  cannabinoid receptor 1 isoform a

      See identical proteins and their annotated locations for NP_001153730.1

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      Consensus CDS
      CCDS5015.1
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
      Related
      ENSP00000446702.2, ENST00000551417.2
      Conserved Domains (1) summary
      cd15340
      Location:117408
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001160259.3NP_001153731.1  cannabinoid receptor 1 isoform a

      See identical proteins and their annotated locations for NP_001153731.1

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      Consensus CDS
      CCDS5015.1
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
      Conserved Domains (1) summary
      cd15340
      Location:117408
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_001365869.2NP_001352798.1  cannabinoid receptor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      Consensus CDS
      CCDS5015.1
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
      Related
      ENSP00000358511.2, ENST00000369499.3
      Conserved Domains (1) summary
      cd15340
      Location:117408
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. NM_001365870.2NP_001352799.1  cannabinoid receptor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      Consensus CDS
      CCDS5015.1
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
      Conserved Domains (1) summary
      cd15340
      Location:117408
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    6. NM_001365872.2NP_001352801.1  cannabinoid receptor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      Consensus CDS
      CCDS5015.1
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
      Conserved Domains (1) summary
      cd15340
      Location:117408
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    7. NM_001365874.3NP_001352803.1  cannabinoid receptor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      Consensus CDS
      CCDS5015.1
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
      Related
      ENSP00000412192.2, ENST00000428600.3
      Conserved Domains (1) summary
      cd15340
      Location:117408
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    8. NM_001370545.1NP_001357474.1  cannabinoid receptor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      Consensus CDS
      CCDS5015.1
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
      Conserved Domains (1) summary
      cd15340
      Location:117408
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    9. NM_001370546.1NP_001357475.1  cannabinoid receptor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      Consensus CDS
      CCDS5015.1
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
      Conserved Domains (1) summary
      cd15340
      Location:117408
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    10. NM_001370547.1NP_001357476.1  cannabinoid receptor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      Consensus CDS
      CCDS5015.1
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
      Conserved Domains (1) summary
      cd15340
      Location:117408
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    11. NM_001424094.1NP_001411023.1  cannabinoid receptor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
    12. NM_001424095.1NP_001411024.1  cannabinoid receptor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
    13. NM_001424096.1NP_001411025.1  cannabinoid receptor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
    14. NM_001424097.1NP_001411026.1  cannabinoid receptor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
    15. NM_001424098.1NP_001411027.1  cannabinoid receptor 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
    16. NM_016083.6NP_057167.2  cannabinoid receptor 1 isoform a

      See identical proteins and their annotated locations for NP_057167.2

      Status: REVIEWED

      Source sequence(s)
      AL121835, AL136096
      Consensus CDS
      CCDS5015.1
      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
      Related
      ENSP00000358513.2, ENST00000369501.3
      Conserved Domains (1) summary
      cd15340
      Location:117408
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    17. NM_033181.4NP_149421.2  cannabinoid receptor 1 isoform b

      See identical proteins and their annotated locations for NP_149421.2

      Status: REVIEWED

      Source sequence(s)
      AY766182, BM682178, BX538191, DA239984, DA793373, DA799263, X54937, X81120
      Consensus CDS
      CCDS5016.2
      UniProtKB/TrEMBL
      Q506J9, V5KA96
      Related
      ENSP00000420188.1, ENST00000468898.2
      Conserved Domains (1) summary
      cd15340
      Location:84375
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      88139864..88167349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418171.1XP_047274127.1  cannabinoid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
    2. XM_047418173.1XP_047274129.1  cannabinoid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
    3. XM_047418172.1XP_047274128.1  cannabinoid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      89348358..89375841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354204.1XP_054210179.1  cannabinoid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
    2. XM_054354206.1XP_054210181.1  cannabinoid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4
    3. XM_054354205.1XP_054210180.1  cannabinoid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
      UniProtKB/TrEMBL
      Q506J9, S5TLS4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001160260.1: Suppressed sequence

      Description
      NM_001160260.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.