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    OSCP1 organic solute carrier partner 1 [ Homo sapiens (human) ]

    Gene ID: 127700, updated on 27-Nov-2024

    Summary

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    Official Symbol
    OSCP1provided by HGNC
    Official Full Name
    organic solute carrier partner 1provided by HGNC
    Primary source
    HGNC:HGNC:29971
    See related
    Ensembl:ENSG00000116885 MIM:608854; AllianceGenome:HGNC:29971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOR1; C1orf102
    Summary
    Enables transmembrane transporter activity. Involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Located in basal plasma membrane and cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 27.5), thyroid (RPKM 6.0) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See OSCP1 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (36417906..36450451, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (36280766..36313305, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36883507..36916052, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36862654-36863366 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36863367-36864078 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36865796-36866392 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36866393-36866988 Neighboring gene uncharacterized LOC124904013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 754 Neighboring gene LSM10, U7 small nuclear RNA associated Neighboring gene RNA, U4 small nuclear 27, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:36886839-36887338 Neighboring gene small nucleolar RNA, H/ACA box 63C Neighboring gene uncharacterized LOC107984940 Neighboring gene Sharpr-MPRA regulatory region 11440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 669 Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:36929292-36930491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36931829-36932691 Neighboring gene colony stimulating factor 3 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36946417-36947202

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE1 nasopharyngeal carcinoma cell line. Nie X, et al. J Cancer Res Clin Oncol, 2003 Jul. PMID 12819961
    2. Tumor suppressor gene Oxidored-nitro domain-containing protein 1 regulates nasopharyngeal cancer cell autophagy, metabolism, and apoptosis in vitro. Li W, et al. Int J Biochem Cell Biol, 2013 Sep. PMID 23831407
    3. [Effects of a novel gene NOR(1) on the protein expression of HepG2 cell line]. Nie XM, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2008 Feb. PMID 18237537
    4. NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma. Li W, et al. Carcinogenesis, 2011 Sep. PMID 21803736
    5. Abberent expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma. Chen S, et al. J Cell Physiol, 2018 Jun. PMID 29227538

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Abberant expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma.
      Title: Abberent expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma.
    2. Results identified NOR1 as a downstream target gene of miR-199a which is critical for regulating cell proliferation and migration by targeting and upregulating NOR1 in human HepG2 cells.
      Title: MicroRNA-199a-5p inhibits VEGF-induced tumorigenesis through targeting oxidored-nitro domain-containing protein 1 in human HepG2 cells.
    3. Data revealed novel aspects of the interplay between autophagy and apoptosis in nasopharyngeal carcinoma cells, which underlies the tumor suppression function of NOR1.
      Title: Tumor suppressor gene Oxidored-nitro domain-containing protein 1 regulates nasopharyngeal cancer cell autophagy, metabolism, and apoptosis in vitro.
    4. Frequent epigenetic inactivation of the NOR1 gene in nasopharyngeal carcinoma (NPC) suggests that it may be a critical tumor suppressor involved in the development of nasopharyngeal carcinoma.
      Title: NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma.
    5. NOR1 protein is predominantly expressed in human nasopharynx and tracheal tissues and is frequently down-expressed in NPC.
      Title: Preparation of polyclonal antibody specific for NOR1 and detection of its expression pattern in human tissues and nasopharyngeal carcinoma.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. NOR(1) gene may have some effects on liver cancer by up-regulating the expression of these proteins.
      Title: [Effects of a novel gene NOR(1) on the protein expression of HepG2 cell line].
    8. We cloned a novel gene NOR(1), and the Glu58Gly polymorphism of NOR(1) may be involved in the development and/or progression of NPC suggesting that NOR(1) could be a candidate tumor repressor gene related with NPC.
      Title: Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE1 nasopharyngeal carcinoma cell line.
    9. hOSCP1 is a novel polyspecific organic solute carrier protein responsible for drug clearance from the human placenta
      Title: Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis for severe diabetic retinopathy.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC26685

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein OSCP1
    Names
    organic solute carrier protein 1
    organic solute transport protein 1
    oxidored nitro domain containing protein
    oxidored-nitro domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330493.2 → NP_001317422.1  protein OSCP1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC119675
      Consensus CDS
      CCDS81301.1
      UniProtKB/Swiss-Prot
      A6NHM5, A6NHS9, A6NIN9, Q4AEJ0, Q8N7G2, Q8TDF1, Q8WVF1
      UniProtKB/TrEMBL
      C9JF58
      Related
      ENSP00000349052.5, ENST00000356637.9

    2. NM_145047.5 → NP_659484.4  protein OSCP1 isoform 1

      See identical proteins and their annotated locations for NP_659484.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
      Source sequence(s)
      AW136490, BC018069, DA297022
      Consensus CDS
      CCDS409.2
      UniProtKB/TrEMBL
      C9JF58
      Related
      ENSP00000235532.5, ENST00000235532.9
      Conserved Domains (1) summary
      pfam10188
      Location:18 → 189
      Oscp1; Organic solute transport protein 1

    3. NM_206837.3 → NP_996668.1  protein OSCP1 isoform 2

      See identical proteins and their annotated locations for NP_996668.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and differs in the 3' coding region and 3' UTR compared to variant 3. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AF086535, BU854079, CN430132, DA297022
      Consensus CDS
      CCDS410.1
      UniProtKB/Swiss-Prot
      Q8WVF1
      Related
      ENSP00000346216.3, ENST00000354267.3
      Conserved Domains (1) summary
      pfam10188
      Location:18 → 172
      Oscp1; Organic solute transport protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      36417906..36450451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005270462.2 → XP_005270519.1  protein OSCP1 isoform X3

      UniProtKB/TrEMBL
      H7C0S2
      Related
      ENSP00000396417.3, ENST00000445843.7
      Conserved Domains (1) summary
      pfam10188
      Location:18 → 199
      Oscp1; Organic solute transport protein 1

    2. XM_011540681.4 → XP_011538983.1  protein OSCP1 isoform X2

      UniProtKB/TrEMBL
      C9JF58
      Conserved Domains (1) summary
      pfam10188
      Location:10 → 161
      Oscp1; Organic solute transport protein 1

    3. XM_011540680.3 → XP_011538982.1  protein OSCP1 isoform X1

      UniProtKB/TrEMBL
      C9JF58
      Conserved Domains (1) summary
      pfam10188
      Location:17 → 171
      Oscp1; Organic solute transport protein 1

    4. XM_047445746.1 → XP_047301702.1  protein OSCP1 isoform X6

    5. XM_047445744.1 → XP_047301700.1  protein OSCP1 isoform X5

    6. XM_005270463.4 → XP_005270520.1  protein OSCP1 isoform X4

      Conserved Domains (1) summary
      pfam10188
      Location:18 → 182
      Oscp1; Organic solute transport protein 1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      36280766..36313305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334378.1 → XP_054190353.1  protein OSCP1 isoform X3

    2. XM_054334377.1 → XP_054190352.1  protein OSCP1 isoform X2

    3. XM_054334376.1 → XP_054190351.1  protein OSCP1 isoform X1

    4. XM_054334381.1 → XP_054190356.1  protein OSCP1 isoform X6

    5. XM_054334380.1 → XP_054190355.1  protein OSCP1 isoform X5

    6. XM_054334379.1 → XP_054190354.1  protein OSCP1 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WVF1.4 GenPept UniProtKB/Swiss-Prot:Q8WVF1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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