TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough [Homo sapiens (human)] - Gene

Summary

Official Symbol: TNFSF12-TNFSF13provided by HGNC
Official Full Name: TNFSF12-TNFSF13 readthroughprovided by HGNC
Primary source: HGNC:HGNC:33537
See related: Ensembl:ENSG00000248871 AllianceGenome:HGNC:33537
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TWE-PRIL
Summary: This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lung (RPKM 41.7), gall bladder (RPKM 26.6) and 25 other tissues See more
Orthologs: all
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Genomic context

See TNFSF12-TNFSF13 in Genome Data Viewer

Location:: 17p13.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (7549058..7561601)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (7453339..7465862)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (7452375..7464918)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. EBI GWAS Catalog EBI GWAS CatalogPubMed
Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide scan identifies variant in TNFSF13 associated with serum IgM in a healthy Chinese male population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

TNFSF12_268.2 (e-PCR)
- UniSTS:277833

RH98958 (e-PCR)
- UniSTS:85338

RH16009 (e-PCR)
- UniSTS:33639

SHGC-56910 (e-PCR)
- UniSTS:7380

General protein information

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Preferred Names: TNFSF12-TNFSF13 protein

Names: tumor necrosis factor (ligand) superfamily, member 12-member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172089.4 → NP_742086.1 TNFSF12-TNFSF13 protein

See identical proteins and their annotated locations for NP_742086.1

Status: REVIEWED

Source sequence(s)

AC016876, AY081051

UniProtKB/TrEMBL

A0A0A6YY99

Related

ENSP00000293826.4, ENST00000293826.4

Conserved Domains (2) summary

cd00184
Location:197 → 328

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

cl00147
Location:131 → 166

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...