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    ZNF284 zinc finger protein 284 [ Homo sapiens (human) ]

    Gene ID: 342909, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF284provided by HGNC
    Official Full Name
    zinc finger protein 284provided by HGNC
    Primary source
    HGNC:HGNC:13078
    See related
    Ensembl:ENSG00000186026 AllianceGenome:HGNC:13078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF284L
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in skin (RPKM 1.1), spleen (RPKM 0.9) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF284 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44072159..44089613)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46895045..46912496)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44576312..44593766)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14750 Neighboring gene zinc finger protein 222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44555855-44556356 Neighboring gene zinc finger protein 223 Neighboring gene RNA, U6 small nuclear 902, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14752 Neighboring gene zinc finger protein 224 Neighboring gene ZNF225 and ZNF224 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44617263-44617613 Neighboring gene zinc finger protein 225

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L). Yin G, et al. Mol Biol Rep, 2006 Jun. PMID 16817023
    2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
    3. Human transcription factor protein interaction networks. Göös H, et al. Nat Commun, 2022 Feb 9. PMID 35140242, Free PMC Article
    4. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
    5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp781F1775

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 284

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037813.4 → NP_001032902.1  zinc finger protein 284

      See identical proteins and their annotated locations for NP_001032902.1

      Status: VALIDATED

      Source sequence(s)
      AC084219, AY458845, BM989725
      Consensus CDS
      CCDS46099.1
      UniProtKB/Swiss-Prot
      Q2VY69, Q86WM1
      Related
      ENSP00000411032.2, ENST00000421176.4
      Conserved Domains (3) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:209 → 554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:205 → 225
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      44072159..44089613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451486.2 → XP_024307254.1  zinc finger protein 284 isoform X1

      UniProtKB/Swiss-Prot
      Q2VY69, Q86WM1
      Conserved Domains (3) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:209 → 554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:205 → 225
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_011526907.4 → XP_011525209.1  zinc finger protein 284 isoform X1

      See identical proteins and their annotated locations for XP_011525209.1

      UniProtKB/Swiss-Prot
      Q2VY69, Q86WM1
      Conserved Domains (3) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:209 → 554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:205 → 225
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_011526908.4 → XP_011525210.1  zinc finger protein 284 isoform X1

      See identical proteins and their annotated locations for XP_011525210.1

      UniProtKB/Swiss-Prot
      Q2VY69, Q86WM1
      Conserved Domains (3) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:209 → 554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:205 → 225
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46895045..46912496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320843.1 → XP_054176818.1  zinc finger protein 284 isoform X1

    2. XM_054320842.1 → XP_054176817.1  zinc finger protein 284 isoform X1

    3. XM_054320841.1 → XP_054176816.1  zinc finger protein 284 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2VY69.1 GenPept UniProtKB/Swiss-Prot:Q2VY69

    Gene LinkOut

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