dnd dead end [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dndprovided by FlyBase
Official Full Name: dead endprovided by FlyBase
Primary source: FLYBASE:FBgn0038916
Locus tag: Dmel_CG6560
See related: AllianceGenome:FB:FBgn0038916
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: arl3; Arl3; ARL3; CG6560; Dmel\CG6560; Dnd; Q9VD64
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in branch fusion, open tracheal system. Located in cytoplasm. Colocalizes with microtubule cytoskeleton. Is expressed in several structures, including adult head; embryonic/larval tracheal section; sense organ; sensory cluster; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Orthologous to human ARL3 (ARF like GTPase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21885676..21887355, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17711398..17713077, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISA Inferred from Sequence Alignment more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISM Inferred from Sequence Model more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed