U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Myo61F Myosin 61F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38153, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Myo61Fprovided by FlyBase
    Official Full Name
    Myosin 61Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010246
    Locus tag
    Dmel_CG9155
    See related
    AllianceGenome:FB:FBgn0010246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9155; Dm IB; Dmel\CG9155; DmIB; DroMIB; IB; Mhc2; MIB; Myo-IB; Myo1B; myo1C; Myo1C; myo61f; myo61F; MYO61F; MyoIB; MYOIB; myoIC; MyoIC
    Summary
    Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including defense response to bacterium; imaginal disc-derived male genitalia morphogenesis; and microvillus organization. Located in brush border and cell cortex. Is expressed in several structures, including adult head; epithelial cell; epithelium; gut section; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human MYO1C (myosin IC) and MYO1H (myosin IH). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Myo61F in Genome Data Viewer
    Location:
    61F6-61F6; 3-0 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1318480..1329617)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1318480..1329617)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ctr9 Neighboring gene sturkopf Neighboring gene HECT and RLD domain containing E3 ubiquitin ligase 4 Neighboring gene long non-coding RNA:CR45166 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) acyl carrier protein Neighboring gene mitotic spindle density 1 Neighboring gene mitotic spindle density 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Effect of temperature on actin filament corkscrewing driven by nonprocessive myosin IC. Sato Y, et al. Biochem Biophys Res Commun, 2024 Apr 9. PMID 38367512
    2. A new myosin I gene in Drosophila. Cheney CM, et al. Biochem Biophys Res Commun, 1993 Sep 30. PMID 8216259
    3. Characterization of myosin-IA and myosin-IB, two unconventional myosins associated with the Drosophila brush border cytoskeleton. Morgan NS, et al. Dev Biol, 1995 Nov. PMID 7589814
    4. Left-right Myosin-Is, Myosin1C, and Myosin1D exhibit distinct single molecule behaviors on the plasma membrane of Drosophila macrophages. Utsunomiya S, et al. Genes Cells, 2024 May. PMID 38454557
    5. The molecular cloning and characterization of Drosophila melanogaster myosin-IA and myosin-IB. Morgan NS, et al. J Mol Biol, 1994 Jun 10. PMID 8201616

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the organ specificities of the Myo31DF and Myo61F activities depended on their head regions
      Title: Head region of unconventional myosin I family members is responsible for the organ-specificity of their roles in left-right polarity in Drosophila.
    2. Myo1B may play a role in the local midgut response pathway of the Imd innate immune response to Gram-negative bacterial infection
      Title: Roles for Drosophila melanogaster myosin IB in maintenance of enterocyte brush-border structure and resistance to the bacterial pathogen Pseudomonas entomophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc-derived male genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in microvillus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    myosin 61F
    Names
    CG9155-PA
    CG9155-PB
    CG9155-PC
    CG9155-PD
    Myo61F-PA
    Myo61F-PB
    Myo61F-PC
    Myo61F-PD
    Myosin-IB
    myosin 1b
    myosin I
    myosin IB
    myosin61F
    NP_476934.2
    NP_728594.2
    NP_728595.1
    NP_728596.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1318480..1329617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167872.2 → NP_728596.1  myosin 61F, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728596.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8F4R0
      Related
      FBpp0072565
      Conserved Domains (3) summary
      smart00242
      Location:6 → 694
      MYSc; Myosin. Large ATPases
      cd01378
      Location:26 → 681
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:837 → 1009
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    2. NM_167871.2 → NP_728595.1  myosin 61F, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728595.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8F4R0
      Related
      FBpp0072566
      Conserved Domains (3) summary
      smart00242
      Location:6 → 694
      MYSc; Myosin. Large ATPases
      cd01378
      Location:26 → 681
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:837 → 1009
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    3. NM_057586.4 → NP_476934.2  myosin 61F, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476934.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8F4R0
      Related
      FBpp0072567
      Conserved Domains (3) summary
      smart00242
      Location:32 → 720
      MYSc; Myosin. Large ATPases
      cd01378
      Location:52 → 707
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:863 → 1035
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    4. NM_167870.2 → NP_728594.2  myosin 61F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728594.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V191, Q23979, Q7KVC1, Q8T0U8, Q9W0H0
      UniProtKB/TrEMBL
      H8F4R0
      Related
      FBpp0072568
      Conserved Domains (3) summary
      smart00242
      Location:15 → 703
      MYSc; Myosin. Large ATPases
      cd01378
      Location:35 → 690
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:846 → 1018
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23979.3 Q23979

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools