GlcAT-I Glucuronyltransferase I [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GlcAT-Iprovided by FlyBase
Official Full Name: Glucuronyltransferase Iprovided by FlyBase
Primary source: FLYBASE:FBgn0066114
Locus tag: Dmel_CG32775
See related: AllianceGenome:FB:FBgn0066114
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH05057; CAA21824; CG32775; dGlcAT-I; DGlcAT-I; Dmel\CG32775; DmGlcAT-I; EG:EG0007.5; GH05057p; GlcAT1; RE38067
Summary: Enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Predicted to be involved in carbohydrate metabolic process and chondroitin sulfate proteoglycan biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic hypopharynx; epipharynx primordium; and gut section. Human ortholog(s) of this gene implicated in Barrett's esophagus; Larsen-like syndrome B3GAT3 type; and schizophrenia. Orthologous to several human genes including B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4131211..4132833)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4025244..4026866)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

novel glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans
Title: Identification and characterization of three Drosophila melanogaster glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans. Two novel homologs exhibit broad specificity toward oligosaccharides from proteoglycans, glycoproteins, and glycosphingolipids.

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Function	Evidence Code	Pubs
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_726910.1

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The following sections contain reference sequences that belong to a specific genome build. Explain