Doc1 Dorsocross1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Doc1provided by FlyBase
Official Full Name: Dorsocross1provided by FlyBase
Primary source: FLYBASE:FBgn0028789
Locus tag: Dmel_CG5133
See related: AllianceGenome:FB:FBgn0028789
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5133; Dm-DOC1; Dmel\CG5133; doc; Doc; Doc-1; doc1; Ect2; ECT2; Tb66F2; TBX6
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including anterior Malpighian tubule development; determination of wing disc primordium; and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on imaginal disc fusion, thorax closure. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; epithelium; germ layer; head epidermis primordium; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 5. Orthologous to human TBX6 (T-box transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66F2-66F3; 3-28 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9041375..9045042)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9034475..9038142)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner.
Title: T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner.
results suggest that Doc regulates the expression of Delta and influence the outcome of Notch signaling in the eye discs
Title: Regulation of Notch signaling in the developing Drosophila eye by a T-box containing transcription factor, Dorsocross.
Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc
Title: The Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc.
Genetic interaction analysis shows that spir functionally interacts with Dorsocross, tin, and pannier to properly specify the cardiac fate.
Title: Spire, an actin nucleation factor, regulates cell division during Drosophila heart development.
Dorsocross genes are required for normal patterning of the dorsolateral ectoderm and, in particular, the repression of wingless and the ladybird homeobox genes within this area of the germ band
Title: The T-box-encoding Dorsocross genes function in amnioserosa development and the patterning of the dorsolateral germ band downstream of Dpp.
Required for the formation of all myocardial and pericardial cell types, with the exception of the Eve-positive pericardial cells.
Title: The Dorsocross T-box genes are key components of the regulatory network controlling early cardiogenesis in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of wing disc primordium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic development via the syncytial blastoderm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_positive_effect imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Dorsocross1

Names: CG5133-PA; CG5133-PB; Doc1-PA; Doc1-PB; dorsocross

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9041375..9045042

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140026.3 → NP_648283.1 Dorsocross1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648283.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MYX3, Q9U8L5, Q9VST3

Related

FBpp0076249

Conserved Domains (1) summary

cd00182
Location:58 → 245

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
NM_001274683.1 → NP_001261612.1 Dorsocross1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261612.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBY6, Q8MYX3

Conserved Domains (1) summary

cd00182
Location:23 → 210

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...